Attenuation of inflammatory response and reduction in infarct size by postconditioning are associated with downregulation of early growth response 1 during reperfusion in rat heart

Shock
Ning-Ping WangZhi-Qing Zhao

Abstract

Early growth response 1 (EGR-1) works as a master regulator that plays a key role in triggering inflammation-induced tissue injury after ischemia and reperfusion. This study tested the hypothesis that postconditioning (Postcon) or anti-inflammatory compound, curcumin, ameliorates inflammatory responses and further reduces infarct size by normalizing EGR-1 expression during reperfusion. In the control group, male Sprague-Dawley rats were subjected to 30-min ischemia and 180-min reperfusion. Postcon with four cycles of 10-s/10-s reperfusion/ischemia was applied at the onset of reperfusion. Curcumin (150 mg/kg per day) was fed 5 days before ischemia. Relative to the control, Postcon reduced expression of EGR-1 mRNA and protein, as further identified by less EGR-1 immunoreactivity in myocardial nuclei and microvessels during reperfusion. Along with EGR-1 downregulation, levels of plasma and myocardial tumor necrosis factor α and interleukin 6 (IL-6) were significantly decreased. Upregulated P-selectin and intercellular adhesion molecule 1 mRNA and protein as well as their immunoreactivity at area at risk myocardium were significantly attenuated. Neutrophil extravasation identified by myeloperoxidase immunohistochemical staining was...Continue Reading

References

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Jul 25, 2012·British Journal of Pharmacology·Ning-Ping WangZhi-Qing Zhao

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Citations

Jul 5, 2019·Molecular Genetics & Genomic Medicine·Xiumin LiuChangyu Wang
Mar 14, 2020·Journal of Clinical Medicine·Bahare SalehiJavad Sharifi-Rad
Mar 19, 2014·Shock·Mark G Clemens
Jul 7, 2018·Experimental and Therapeutic Medicine·Shi WangLiting Chen
Jul 9, 2020·Therapeutic Advances in Chronic Disease·Sophie MoulinElise Belaidi
Aug 25, 2017·Nature Reviews. Cardiology·Francine Z MarquesDavid M Kaye
Mar 17, 2021·Briefings in Bioinformatics·Stephen DoranAdil Mardinoglu
Aug 31, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Dejing ShiHongxia Wang
Nov 11, 2021·Journal of the American Heart Association·Levon M Khachigian

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