Attenuation of intestinal ischemia-reperfusion-injury by β-alanine: a potentially glycine-receptor mediated effect

The Journal of Surgical Research
Lisa BrencherMichael Kirsch

Abstract

Acute mesenteric ischemia is often caused by embolization of the mesenteric arterial circulation. Coherent intestinal injury due to ischemia and following reperfusion get visible on macroscopic and histologic level. In previous studies, application of glycine caused an ameliorated intestinal damage after ischemia-reperfusion in rats. Because we speculated that glycine acted here as a signal molecule, we investigated whether the glycine-receptor agonist β-alanine evokes the same beneficial effect in intestinal ischemia-reperfusion. β-alanine (10, 30, and 100 mg/kg) was administered intravenously. Ischemia/reperfusion of the small intestine was initiated by occluding and reopening the superior mesenteric artery in rats. After 90 min of ischemia and 120 min of reperfusion, the intestine was analyzed with regard to macroscopic and histologic tissue damage, the activity of the saccharase, and accumulation of macrophages. In addition, systemic parameters and metabolic ones (e.g., acid-base balance, electrolytes, and blood glucose) were measured at certain points in time. All three dosages of β-alanine did not change systemic parameters but prevent from hyponatremia during the period of reperfusion. Most importantly, application of 10...Continue Reading

Citations

Dec 5, 2017·BioMed Research International·Lisa BrencherMichael Kirsch
Jul 20, 2018·Cell Biology International·Iryna LushnikovaGalyna Skibo
Apr 10, 2020·Khirurgiia·A I KhripunG A Agasyan
Jun 6, 2018·BMC Anesthesiology·Daniel C SchroederMaria Guschlbauer
Jan 29, 2020·Applied Microbiology and Biotechnology·Xinyu ZouZhibin Feng
Dec 3, 2020·Vascular Health and Risk Management·María Noelia AlonsoFrancisco Álvarez-Marcos
Feb 28, 2021·The Journal of Surgical Research·Lisa Dominowski, Michael Kirsch

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