Attenuation of iodine 125 radiation with vitreous substitutes in the treatment of uveal melanoma

Archives of Ophthalmology
Scott C N OliverT A McCannel

Abstract

To demonstrate attenuation of radiation from iodine 125 ((125)I) to intraocular structures using liquid vitreous substitutes. Four candidate vitreous substitutes were tested for attenuation using empirical measurement and theoretical calculation. In vitro and ex vivo cadaveric dosimetry measurements were obtained with lithium fluoride thermoluminescent dosimeters to demonstrate the attenuation effect of vitreous substitution during (125)I simulated plaque brachytherapy. Theoretical dosimetry calculations were based on Monte Carlo simulation. In a cylindrical phantom at a 17-mm depth, liquid vitreous substitutes as compared with saline showed significant reduction of radiation penetration (48% for 1000-centistoke [cSt] silicone oil [polydimethyl-n-siloxane], 47% for 5000-cSt silicone oil [polydimethyl-n-siloxane], 40% for heavy oil [perfluorohexyloctane/polydimethyl-n-siloxane], and 35% for perfluorocarbon liquid [perfluoro-n-octane]). Human cadaveric ex vivo measurements demonstrated a 1000-cSt silicone oil to saline dose ratio of 35%, 52%, 55%, and 48% at arc lengths of 7.6, 10.6, 22.3, and 28.6 mm from the plaque edge, respectively, along the surface of the globe. Monte Carlo simulation of a human globe projected attenuation ...Continue Reading

Citations

Apr 16, 2016·Seminars in Ophthalmology·Meghna V MotianiTara A McCannel
Apr 12, 2014·International Journal of Radiation Oncology, Biology, Physics·Tara A McCannel, Colin A McCannel
Jun 5, 2012·International Journal of Radiation Oncology, Biology, Physics·Gaurav MarwahaArun D Singh
Sep 18, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tara A McCannelColin A McCannel
Mar 15, 2018·Current Opinion in Ophthalmology·David Reichstein, Kayla Karan
Aug 29, 2012·Ophthalmic Research·Arun D SinghMary E Aronow
Jan 25, 2019·Ocular Oncology and Pathology·Nima FatehiKouros Nouri-Mahdavi
Dec 2, 2014·International Ophthalmology Clinics·Hassan A Aziz, Arun D Singh
Jun 10, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·John V HegdeMitchell Kamrava
Oct 24, 2020·International Ophthalmology Clinics·Basil K Williams, Maura Di Nicola

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