Attenuation of kindling-induced decreases in NT-3 mRNA by thyroid hormone depletion

Epilepsy Research
S Y KimJ B Rosen

Abstract

The expression of neurotrophins is altered by amygdala kindled seizures. Because thyroid hormone can regulate the transcription of neurotrophins, we asked whether thyroid hormone regulates neurotrophin mRNA expression following amygdala kindling. Rats with electrodes implanted in the basolateral nucleus of the amygdala were either depleted of thyroid hormone or given excess thyroid hormone. The rats were then kindled daily until they had one generalized seizure. The brains were removed 4 h after the seizure and processed for in situ hybridization of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) mRNAs. In non-kindled rats, thyroid hormone depletion increased the levels of BDNF mRNA in the paraventricular nucleus of the hypothalamus and the pituitary gland. NGF and NT-3 mRNA expression was not altered. In addition, thyroid hormone manipulations had no effect on kindling or on kindling-induced BDNF and NGF mRNA. However, the kindling-induced decrease in NT-3 mRNA expression in the dentate gyrus granule cell layer was significantly attenuated by thyroid hormone depletion. These effects were reversed by thyroid hormone replacement. The results indicate that thyroid hormone plays a modu...Continue Reading

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Citations

Dec 22, 2000·Progress in Neurobiology·J L Jankowsky, P H Patterson
Jan 27, 2004·Seizure : the Journal of the British Epilepsy Association·Adem AydinBaris Baklan
Apr 17, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Helen E Scharfman
Sep 13, 2015·Seizure : the Journal of the British Epilepsy Association·Seyedeh Masoumeh Seyedhoseini TamijaniAbolhassan Ahmadiani
Oct 25, 2011·Brain Research·Rashmi M RisbudBrenda E Porter
Oct 24, 2006·Trends in Pharmacological Sciences·Michele SimonatoMerab Kokaia

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