PMID: 11605937Oct 19, 2001Paper

Attenuation of lung inflammation by adrenergic agonists in murine acute lung injury

Anesthesiology
V K DhingraK R Walley

Abstract

Acute lung injury leading to a systemic inflammatory response greatly increases mortality in critically ill patients. Cardiovascular management of these patients frequently involves beta-adrenergic agonists. These agents may alter the inflammatory response. Therefore, the authors tested the hypothesis that beta-adrenergic agonists alter the pulmonary inflammatory response during acute lung injury in mice. Five-week-old CD-1 mice received continuous infusions of 10 microg x kg(-1) x min(-1) dobutamine, 6 microg x kg(-1) x min(-1) dopexamine, or vehicle via intraperitoneal mini osmotic pumps, followed immediately by intratracheal instillation of approximately 2 microg/kg endotoxin (or phosphate-buffered saline control). Six hours later the mice were killed, and lung lavage was performed. Interleukin-6 and -10 concentrations in lung homogenates were measured using enzyme-linked immunosorbent assay. Interleukin-6 and macrophage inflammatory protein-2 mRNA was measured using reverse-transcription polymerase chain reaction. Interleukin-6 protein and mRNA significantly increased after intratracheal endotoxin (P < 0.001), and the fraction of neutrophils in lung lavage fluid increased in endotoxin-treated (41 +/- 25%) versus control mic...Continue Reading

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Citations

May 16, 2003·Vascular Pharmacology·A B Johan Groeneveld
May 16, 2003·Vascular Pharmacology·Geerten P van Nieuw Amerongen, Victor W M van Hinsbergh
Feb 10, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Markus BosmannPeter A Ward
Apr 25, 2006·Critical Care Medicine·A B Johan GroeneveldMargriet F C de Jong
Feb 21, 2004·Critical Care : the Official Journal of the Critical Care Forum·Gavin D PerkinsFang Gao
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Horacio E GroshausJames A Russell
Jan 20, 2006·Critical Care : the Official Journal of the Critical Care Forum·Sanjay ManochaJames A Russell
Jun 3, 2008·Critical Care : the Official Journal of the Critical Care Forum·Oriol RocaJoan R Masclans
Jun 19, 2009·Anesthesia and Analgesia·Michael T PawlikKarl P Ittner
Jun 5, 2003·Environmental Health Perspectives·John K McGeeStephen H Gavett
Mar 6, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Franco ValenzaLuciano Gattinoni
Oct 28, 2008·Resuscitation·John H BoydKeith R Walley
Oct 28, 2008·The Journal of Surgical Research·Ankush GosainLuisa A DiPietro
Jun 27, 2002·Expert Opinion on Pharmacotherapy·C C dos SantosA S Slutsky
Aug 21, 2020·Seminars in Respiratory and Critical Care Medicine·James A RussellNiranjan Kissoon

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