Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8(+) T cells in the nigra of hemiparkinsonian monkey

Neuroscience
Avik RoyKalipada Pahan

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Despite intense investigations, little is known about its pathological mediators. Here, we report the marked upregulation of RANTES (regulated on activation, normal T cell expressed and secreted) and eotaxin, chemokines that are involved in T cell trafficking, in the serum of hemiparkinsonian monkeys. Interestingly, 1-methyl-4-phenylpyridinium (MPP(+)), a Parkinsonian toxin, increased the expression of RANTES and eotaxin in mouse microglial cells. The presence of NF-κB binding sites in promoters of RANTES and eotaxin and down-regulation of these genes by NEMO-binding domain (NBD) peptide, selective inhibitor of induced NF-κB activation, in MPP(+)-stimulated microglial cells suggest that the activation of NF-κB plays an important role in the upregulation of these two chemokines. Consistently, serum enzyme-linked immuno assay (ELISA) and nigral immunohistochemistry further confirmed that these chemokines were strongly upregulated in MPTP-induced hemiparkinsonian monkeys and that treatment with NBD peptides effectively inhibited the level of these chemokines. Furth...Continue Reading

References

Aug 4, 1998·The Journal of Experimental Medicine·F HadidaP Debré
Mar 3, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T WadaH Yokoyama
Oct 16, 2002·Glia·Uwe-Karsten Hanisch
Mar 17, 2004·Journal of Neuroimmunology·Sergey G KremlevCharles Palmer
Mar 23, 2006·The Journal of Biological Chemistry·Avik RoyKalipada Pahan
Jan 16, 2007·Nature Reviews. Immunology·V Hugh PerryClive Holmes
Jul 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adám DénesNancy Rothwell
Jun 28, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Saurabh Khasnavis, Kalipada Pahan
Jun 5, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Susanta MondalKalipada Pahan
Oct 15, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Saurabh KhasnavisKalipada Pahan

❮ Previous
Next ❯

Citations

Apr 28, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Goutam ChandraKalipada Pahan
Apr 4, 2019·Frontiers in Neurology·Marie Therese Fuzzati-ArmenteroFabio Blandini
Mar 13, 2019·Frontiers in Immunology·Francesca GarrettiDavid Sulzer
Mar 11, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rodney M RitzelLouise D McCullough
May 27, 2016·The Journal of Biological Chemistry·Goutam ChandraKalipada Pahan
May 3, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanta MondalKalipada Pahan
Jan 14, 2020·Brain, Behavior, and Immunity·Wenxia ZhengHuifang Xie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
Sen QiaoJing-hua Jin
Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology
Susanta MondalKalipada Pahan
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Anamitra GhoshKalipada Pahan
Proceedings of the National Academy of Sciences of the United States of America
Anamitra GhoshKalipada Pahan
© 2021 Meta ULC. All rights reserved