Attenuation of MODS-related and ARDS-related mortality makes infectious complications a remaining challenge in the severely injured

Trauma Surgery & Acute Care Open
Karlijn J P van WessemLuke P H Leenen

Abstract

The recent decrease in multiple organ dysfunction syndrome (MODS)-associated and adult respiratory distress syndrome (ARDS)-associated mortality could be considered a success of improvements in trauma care. However, the incidence of infections remains high in patients with polytrauma, with high morbidity and hospital resources usage. Infectious complications might be a residual effect of the decrease in MODS-related/ARDS-related mortality. This study investigated the current incidence of infectious complications in polytrauma. A 5.5-year prospective population-based cohort study included consecutive severely injured patients (age >15) admitted to a (Level-1) trauma center intensive care unit (ICU) who survived >48 hours. Demographics, physiologic and resuscitation parameters, multiple organ failure and ARDS scores, and infectious complications (pneumonia, fracture-related infection, meningitis, infections related to blood, wound, and urinary tract) were prospectively collected. Data are presented as median (IQR), p<0.05 was considered significant. 297 patients (216 (73%) men) were included with median age of 46 (27-60) years, median Injury Severity Score was 29 (22-35), 96% sustained blunt injuries. 44 patients (15%) died. One ...Continue Reading

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Jan 10, 2019·Trauma Surgery & Acute Care Open·Karlijn J P van Wessem, Luke P H Leenen
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Citations

Dec 16, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Karlijn J P van Wessem, Luke P H Leenen
Nov 13, 2020·Trauma Surgery & Acute Care Open·Karlijn van WessemLuke Leenen

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