Attenuation of mycotoxin-induced IgA nephropathy by eicosapentaenoic acid in the mouse: dose response and relation to IL-6 expression

The Journal of Nutritional Biochemistry
Yuhui Shi, J J Pestka

Abstract

Clinical trials have revealed that progression of immunoglobulin A nephropathy (IgAN), the most common form of human glomerulonephritis, is inhibited by dietary (n-3) polyunsaturated fatty acid (PUFA) supplementation. The early stages of IgAN can be mimicked by feeding mice the mycotoxin deoxynivalenol (DON). Here, the effects of consuming the (n-3) PUFA eicosapentaenoic acid (EPA) on DON-induced IgAN were assessed relative to dose dependency and to expression of interleukin (IL-6). In the dose-response study, weight gain and feed intake did not differ among mice consuming 20 ppm DON supplemented with 0%, 0.1%, 0.5% and 3% EPA for 16 weeks. Mice fed the two highest EPA concentrations exhibited markedly increased splenic EPA, docosapentaenoic acid and docosahexaenoic acid, whereas arachidonic acid was decreased in all three EPA fed groups. Deoxynivalenol consumption significantly increased serum IgA and IgA immune complexes as well as kidney mesangial IgA deposition. All three IgAN markers were attenuated in mice fed 3% EPA diet but not in those fed 0.1% or 0.5% EPA. Elevated IgA production was observed in spleen and Peyer's patch (PP) cell cultures derived from mice fed DON in control diets, but this was reduced in cultures fro...Continue Reading

Citations

Apr 2, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yuhui ShiJames J Pestka
Jul 26, 2011·Clinical & Developmental Immunology·Yusuke SuzukiYasuhiko Tomino
May 27, 2014·Toxins·Philippe Pinton, Isabelle P Oswald
Jul 17, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jacqueline Van De WalleYvan Larondelle
May 25, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Robert G FassettJeff S Coombes
Dec 30, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Zhihua RenJing Fang
Sep 3, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D KeltonD W L Ma
Mar 2, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·James J Pestka
May 24, 2016·International Journal of Molecular Sciences·Amit SharmaJohn D Imig
Jan 9, 2008·Molecular Immunology·Katie LoniewskiNarayanan Parameswaran
Dec 5, 2008·American Journal of Physiology. Renal Physiology·Joseph H GarmanChristine Maric
Jul 8, 2021·Seminars in Immunopathology·Renato C Monteiro, Yusuke Suzuki
Sep 15, 2021·Critical Reviews in Food Science and Nutrition·Silu HouYaxian Yan

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