Attenuation of neuromotor deficits by natural antioxidants of Decalepis hamiltonii in transgenic Drosophila model of Parkinson's disease

Neuroscience
S R JahromiS R Ramesh

Abstract

Oxidative stress is believed to be a major factor for the onset of Parkinson's disease (PD). In this study, we have investigated oxidative status in transgenic Drosophila model of PD. Our results revealed elevated levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) in A30P and A53T α-synuclein PD model flies compared to control. We have demonstrated for the first time the ameliorating potential of natural antioxidants characterized from the roots of Dh in A30P and A53T α-synuclein PD model flies. Feeding of transgenic flies with aqueous Dh root extract for 21 days significantly improved their climbing ability and circadian rhythm of locomotor activity which was associated with reduction in levels of ROS and LPO and enhancement in the activities of catalase (CAT) and superoxide dismutase (SOD). Dh protected against paraquat (PQ) sensitivity in α-synuclein transgenic flies and delayed the onset of PD-like symptoms which appears to be mediated by suppression of oxidative stress.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Oct 1, 1989·Neuron·M Rosbash, J C Hall
Mar 1, 1974·Analytical Biochemistry·M J Black, R B Brandt
Apr 4, 2000·Nature·M B Feany, W W Bender
Jun 26, 2004·Current Neurology and Neuroscience Reports·William C Koller, Maria G Cersosimo
Sep 29, 2004·Lancet·Marie-Christine Chartier-HarlinAlain Destée
Jul 1, 2005·Current Neurology and Neuroscience Reports·K Ray ChaudhuriP Martinez-Martin
Jun 30, 2006·Journal of Neurochemistry·Barry Halliwell
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Cesare MancusoVittorio Calabrese
Jan 6, 2007·Journal of Proteome Research·Zhiyin XunDavid E Clemmer
Mar 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anathbandhu ChaudhuriJanis M O'Donnell
Apr 5, 2007·Nature Protocols·Ezio Rosato, Charalambos P Kyriacou
May 8, 2007·Journal of Neuropathology and Experimental Neurology·Irene LitvanEldad Melamed
Aug 9, 2007·Journal of Proteome Research·Zhiyin XunDavid E Clemmer
Mar 18, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·J Jankovic
Oct 22, 2008·Biochimica Et Biophysica Acta·Talene A Yacoubian, David G Standaert
Oct 22, 2008·Genes & Nutrition·David VauzourJeremy P E Spencer
Feb 27, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Ana Maria CuervoMarta Martinez-Vicente
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jan BieschkeErich E Wanker
Oct 13, 2010·Journal of Geriatric Psychiatry and Neurology·Lynn M BekrisCyrus P Zabetian
Dec 7, 2010·Biochemical and Biophysical Research Communications·Rituraj PalMahesh Narayan
Dec 9, 2010·Journal of Neurochemistry·Jeswinder Sian-HülsmannPeter Riederer
Apr 23, 2011·Parkinson's Disease·Verónica Muñoz-Soriano, Nuria Paricio
Jan 16, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yasir Hasan SiddiqueFalaq Naz
Nov 5, 2013·Behavioural Brain Research·Mohammad HaddadiS R Ramesh
Sep 15, 2011·Food Chemistry·Anup Srivastava, T Shivanandappa

❮ Previous
Next ❯

Citations

Mar 31, 2016·Environmental Toxicology and Pharmacology·Yasir Hasan SiddiqueSaba Khanam
Mar 31, 2016·Neuroscience and Biobehavioral Reviews·Tetsuya AsakawaYing Xia
May 6, 2016·Neuromolecular Medicine·Liting HangKah-Leong Lim
Jul 19, 2018·Toxicology Mechanisms and Methods·Saba KhanamYasir Hasan Siddique
Jan 16, 2020·Antioxidants·Federica De LazzariMarco Bisaglia
Apr 25, 2018·Frontiers in Neurology·Yulan Xiong, Jianzhong Yu
Jun 16, 2017·Journal of Inflammation·Navdeep SinghAnurag Kuhad
Jul 6, 2016·Molecular and Cellular Biochemistry·Tekupalli RavikiranDundaiah Bhagyalakshmi
Aug 28, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jefferson J SoaresElton L G Denardin
Jun 15, 2021·Disease Models & Mechanisms·Stephanie M PützThomas Raabe
Jun 15, 2021·Journal of the American College of Nutrition·Ranjana HimalianMahendra Pratap Singh
May 17, 2021·Food Research International·Yang YiHong-Xun Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alpha-Synuclein Aggregation

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Atypical Parkinsonism (MDS)

Atypical Parkinsonism presents with the same signs and symptoms of Parkinson's disease, but do not respond to typical Parkionson's disease treatment with levodopa. Atypical Parkinsonism is thought to be associated with abnormal protein buildup within brain cells. Here is the latest on Atypical Parkinsonism.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.