Attenuation of neutrophil and endothelial activation by intravenous morphine in patients with acute myocardial infarction

The American Journal of Cardiology
T L WangY Z Tseng

Abstract

To investigate the effects of morphine on neutrophil and endothelial activation, we measured serum levels of intercellular adhesion molecule-1 (ICAM-1), L-selectin, and neutrophil endopeptidase 24.11 (NEP) in 38 patients with acute myocardial infarction (group 1) and 16 control subjects (group 2). In group 1, all the patients underwent blood sampling at initial presentation and 10 minutes later. Twenty of them had 3 mg of morphine administered intravenously immediately after the first sampling (group 1A) and the other 18 after a second sampling (group 1B). The serum levels of ICAM-1 and L-selectin were both significantly higher in groups 1A and 1B than in group 2. In group 1A, the ICAM-1 decreased significantly at second blood samplings (310 +/- 28 vs 368 +/- 30 ng/ml; p <0.001), whereas in group 1B there was no significant change in ICAM-1 (357 +/- 33 vs 359 +/- 26 ng/ml; p = NS). In group 1A, the L-selectin decreased significantly at second blood samplings (2.3 +/- 1.2 mg/L, p <0.001 vs baseline), whereas in group 1B there was no significant change in L-selectin (3.9 +/- 1.0 mg/L, p = NS vs baseline). There was no significant difference in baseline NEP activities between groups 1A and 1B (4.89 +/- 1.22 vs 5.14 +/- 1.57 nmol/m...Continue Reading

References

Dec 4, 1992·Annals of the New York Academy of Sciences·A J GearingS J Cashman
May 22, 1990·The American Journal of Cardiology·B R Lucchesi
Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Jan 30, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M A ShippE L Reinherz
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G B StefanoB Scharrer
Sep 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G K HanssonS Stemme
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M A ShippE L Reinherz
Oct 1, 1988·The Journal of Experimental Medicine·M LetarteR R McInnes
Jan 1, 1986·Annals of the New York Academy of Sciences·G W Pasternak
Jun 1, 1988·Journal of the American College of Cardiology·J L MehtaP Mehta
Feb 20, 1986·The New England Journal of Medicine·R Ross
Dec 1, 1986·Atherosclerosis·J Nilsson
Oct 1, 1993·Immunology Today·A J Gearing, W Newman
Oct 1, 1994·Current Opinion in Cell Biology·S D Rosen, C R Bertozzi
Nov 1, 1993·The Annals of Thoracic Surgery·W E CurtisT J Gardner
May 1, 1991·Trends in Cardiovascular Medicine·C W SmithM L Entman

❮ Previous
Next ❯

Citations

Apr 3, 2001·The Journal of Experimental Medicine·A Hafezi-MoghadamK Ley
Aug 6, 2002·Cardiovascular Research·Ryan M FryerGarrett J Gross
Oct 11, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Rie Kato, Pierre Foëx
Apr 11, 2002·Acta Anaesthesiologica Scandinavica·Hilchen T Sommerschild, Knut Arvid Kirkebøen
Jul 14, 2005·Expert Opinion on Drug Safety·Amit DindaPravin C Singhal
Aug 8, 2007·Scandinavian Cardiovascular Journal : SCJ·Ayten BilirImran Kurt
May 6, 2004·The Journal of Surgical Research·Matthew A RomanoSteven F Bolling
Dec 20, 2005·Urology·Amirali Hassanzadeh SalmasiAhmad Reza Dehpour
Aug 23, 2005·Pharmacology & Therapeutics·Nobuhisa IwataTakaomi C Saido
Feb 3, 2011·Journal of Korean Medical Science·Too Jae MinYoung Cheol Park
Dec 19, 2008·American Journal of Therapeutics·Jamil DarroujRohit Arora
Oct 29, 2009·Anesthesia and Analgesia·Gordon T C WongMichael G Irwin
Apr 17, 2021·BMC Cardiovascular Disorders·Zahra JalaliAli Esmaeili Nadimi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.