Attenuation of neutrophil function by inhibitors of arachidonate metabolism reduces the extent of canine myocardial infarction

The American Journal of Cardiology
S HoshidaM Tada

Abstract

To assess the role of neutrophils and arachidonate metabolites in evolving myocardial infarction, the effect of inhibitors of arachidonate metabolism on the extent of myocardial damage and neutrophil function was examined in a 90-minute occlusion/5-hour reperfusion model of canine myocardial infarction. A thromboxane A2 synthetase inhibitor, CV-4151, and a lipoxygenase inhibitor, AA-861, greatly reduced the infarct size. They also attenuated the production of chemoattractant leukotriene B4 and chemotactic activity of neutrophils isolated from peripheral circulation. Under these conditions, both the increases in peripheral leukocyte count and neutrophil infiltration in ischemic myocardium were inhibited. These results indicate that the inhibition of 2 pathways of arachidonate metabolism may decrease infiltration of activated neutrophils in ischemic myocardium by attenuating chemotactic function of neutrophils, resulting in reduction of the extent of myocardial infarction.

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Citations

Feb 1, 1993·The International Journal of Biochemistry·T Siminiak, T Ozawa
Jul 1, 1996·Critical Reviews in Oncology/hematology·C Denzlinger
Jul 25, 2007·Journal of Gastroenterology and Hepatology·Hongzhi XuJian X Zhang
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Jun 27, 2021·Mechanisms of Ageing and Development·Vera PilsIngo Lämmermann

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