PMID: 16520296Mar 8, 2006Paper

Attenuation of neutrophil infiltration and proinflammatory cytokines by Cissus quadrangularis: a possible prevention against gastric ulcerogenesis

Journal of Herbal Pharmacotherapy
Mallika Jainu, Chennam Srinivasulu Shyamala Devi

Abstract

Reactive oxygen species, neutrophil infiltration and proinflammatory cytokines play an important role in the pathogenesis of gastric ulcers caused by aspirin. The present study demonstrates the healing effect of Cissus quadrangularis extract (CQE) through inhibitory action on generation of lipid peroxidation, proinflammatory cytokines and neutrophil infiltration. The concentration ofmalondialdehye (MDA), protein carbonyl content, conjugated dienes, mucosal (SH) sulphydryls, uric acid, tumor necrosis factor-alpha (TNF-alpha), and activities of myeloperoxidase (MPO), xanthine oxidase (XO) and antioxidative enzymes were determined in the gastric mucosa. Administration of CQE significantly attenuated the gastric lesions induced by aspirin and this was accompanied by the rise in uric acid, antioxidative enzymes, SH groups, and a significant decrease in lipid peroxidase, TNF-alpha, MPO and XO activities. These findings suggest that the significant gastroprotective activity could be mediated by the antioxidant activity as well as by the attenuation of oxidative mechanism and proinflammatory cytokines.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1992·The International Journal of Biochemistry·T StelmaszyńskaR J Schaur
Oct 1, 1991·The Journal of Pharmacy and Pharmacology·G P GargC W Ogle
May 15, 1986·Archives of Biochemistry and Biophysics·I Fridovich
Jun 1, 1972·Analytical Biochemistry·A K Sinha
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Sep 8, 1970·Biochimica Et Biophysica Acta·R A Klein
Feb 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A CasiniC Surrenti
Jan 1, 1999·Journal of Clinical Gastroenterology·T ArakawaT Kuroki
Aug 26, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·I VillegasC Alarcón de la Lastra
Sep 11, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·B GalunskaA Di Massa
Aug 26, 2003·Journal of Medicinal Food·K N Chidambara MurthyG A Ravishankar
Nov 13, 2003·Journal of Ethnopharmacology·Annie ShirwaikarS Malini

❮ Previous
Next ❯

Citations

Feb 24, 2007·Acta Biotheoretica·Wim J van der Steen, Vincent K Y Ho
Jul 11, 2012·Journal of Osteoporosis·Jameela BanuGabriel Fernandes
Feb 29, 2008·Journal of Ethnopharmacology·Mariana de Paula FerreiraClélia Akiko Hiruma-Lima
Sep 15, 2012·Phytotherapy Research : PTR·Sidney J Stohs, Sidhartha D Ray

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.