PMID: 2115007Jun 1, 1990Paper

Attenuation of perfluoropolymer fume pulmonary toxicity: effect of filters, combustion method, and aerosol age

Experimental and Molecular Pathology
D B WarheitM A Hartsky

Abstract

Thermal decomposition products of some perfluorinated polymers are toxic to experimental animals in small-scale combustion toxicity tests; the toxicity is dependent upon the heating procedure, combustion temperature, and other experimental conditions. In the current studies we investigated the time course of fume generation and exposure on pulmonary effects in rats following a 30-min exposure to perfluoropolymer decomposition products (i.e., fume concentration = 0.2 mg/m3 of tetrafluoroethylene/hexafluoropropylene copolymer (FEP)) pyrolyzed with either static or dynamic airflows. In the first set of experiments, five different groups of rats were exposed to FEP fumes in a static combustion toxicity test system. Three groups were exposed to unfiltered FEP fumes during 0- to 15-, 15- to 30-, and 0- to 30-min intervals, respectively, and one to a filtered (particle-free) atmosphere of combusted FEP for 30 min. Sham-exposed rats constituted the control group. Immediately after exposure, the rats were sacrificed and their lungs weighed and lavaged or perfused to assess indices of cytotoxicity. Our results showed that lung weights, markers of inflammation, and pulmonary hemorrhage and alkaline phosphatase, beta-glucuronidase, lactate...Continue Reading

References

Nov 1, 1975·American Industrial Hygiene Association Journal·G J Sem, K Tsurubayashi
Jan 1, 1968·American Industrial Hygiene Association Journal·R S Waritz, B K Kwon
Apr 1, 1984·Environmental Research·M Sjöstrand, R Rylander
Jan 24, 1959·Journal of the American Medical Association·M L CLAYTON, D A TURNER

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Citations

Jul 1, 1992·Acta Astronautica·R D IronsJ Schulz
Jul 14, 2001·Occupational and Environmental Medicine·M DennekampA Seaton
Jan 21, 1995·Lancet·A SeatonD Godden
Sep 10, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Hannah L Hays, Henry Spiller
Mar 1, 1997·Toxicology and Applied Pharmacology·A F HubbsJ Parker
Dec 14, 2017·Journal of Occupational Medicine and Toxicology·Paul T J ScheepersAsger W Nørgaard
Oct 24, 2000·Toxicology and Applied Pharmacology·C J JohnstonG Oberdörster

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