PMID: 6410440Jan 1, 1983Paper

Attenuation of pilocarpine-induced hypothermia in response to chronic administration of choline

Psychopharmacology
N PomaraS Gershon

Abstract

Chronic treatment of rats with choline caused a decrease in the hypothermic response to pilocarpine. The action of choline on the muscarinic receptors is consistent with electrophysiological and binding studies, supporting a direct muscarinic action for choline. Administration of direct muscarinic agonists has been shown to cause a decrease in the number of muscarinic receptors. Thus, the long-term use of cholinergic precursors could have some adverse effects on central cholinergic functioning.

References

Sep 1, 1966·International Journal of Neuropharmacology·P Lomax, D J Jenden
Jul 30, 1982·Science·R T BartusA S Lippa
Aug 27, 1981·European Journal of Pharmacology·J Ben-BarakY Dudai

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Citations

Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·R I BlockK Braverman
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·O M Almeida, R Santos
Jan 9, 1999·European Journal of Pharmacology·C B UnalI H Ulus
Nov 1, 1984·Clinical and Experimental Pharmacology & Physiology·L G Costa, S D Murphy

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