Abstract
Neurogranin (Ng) is a brain-specific, postsynaptically located protein kinase C (PKC) substrate, highly expressed in the cortex, hippocampus, striatum, and amygdala. This protein is a Ca(2+)-sensitive calmodulin (CaM)-binding protein whose CaM-binding affinity is modulated by phosphorylation and oxidation. To investigate the role of Ng in neural function, a strain of Ng knockout mouse (KO) was generated. Previously we reported (Pak, J. H., Huang, F. L., Li, J., Balschun, D., Reymann, K. G., Chiang, C., Westphal, H., and Huang, K.-P. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 11232-11237) that these KO mice displayed no obvious neuroanatomical abnormality, but exhibited deficits in learning and memory and activation of Ca(2+)/CaM-dependent protein kinase II. In this report, we analyzed several downstream phosphorylation targets in phorbol 12-myristate 13-acetate- and forskolin-treated hippocampal slices from wild type (WT) and KO mice. Phorbol 12-myristate 13-acetate caused phosphorylation of Ng in WT mice and promoted the translocation of PKC from the cytosolic to the particulate fractions of both the WT and KO mice, albeit to a lesser extent in the latter. Phosphorylation of downstream targets, including mitogen-activated prot...Continue Reading
References
Jan 10, 1992·Science·J Posada, J A Cooper
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J B WatsonR S Fisher
Apr 1, 1992·Journal of Neurochemistry·E KlannJ D Sweatt
May 16, 1990·Biochemical and Biophysical Research Communications·T MiyasakaA R Saltiel
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K P HuangF L Huang
Jan 1, 1995·Journal of Neurochemistry·M R Martzen, J R Slemmon
Apr 1, 1995·The European Journal of Neuroscience·N B FedorovK G Reymann
Nov 1, 1993·Journal of Neurochemistry·R S FioreJ M Baraban
Jun 9, 1995·The Journal of Biological Chemistry·G M RamakersW H Gispen
Dec 1, 1994·Brain Research. Molecular Brain Research·J B WatsonP M Coulter
Nov 1, 1993·Journal of Neurochemistry·D M Chetkovich, J D Sweatt
Sep 1, 1993·Archives of Biochemistry and Biophysics·K P HuangH C Chen
Aug 16, 1996·Science·J XingM E Greenberg
Sep 13, 1996·The Journal of Biological Chemistry·F S SheuK P Huang
Sep 9, 1996·Brain Research·M Neuner-JehleJ Mallet
Nov 15, 1996·The Journal of Biological Chemistry·C W MahoneyK P Huang
Apr 4, 1997·Cell·M R VosslerP J Stork
Dec 13, 1997·Molecular Neurobiology·D D Gerendasy, J G Sutcliffe
Jan 27, 1998·The Journal of Biological Chemistry·K N DalbyP Cohen
Feb 28, 1998·Science·K P GieseA J Silva
Apr 8, 1998·Annual Review of Neuroscience·A J SilvaS Kida
Aug 4, 1998·Molecular Pharmacology·W J Tang, J H Hurley
Nov 10, 1998·Neuron·S ImpeyD R Storm
Dec 18, 1998·Science·H KawasakiA M Graybiel
Jan 9, 1999·The Journal of Biological Chemistry·J LiK P Huang
Mar 13, 1999·The Journal of Biological Chemistry·L PrichardD R Storm
Apr 10, 1999·Nature Neuroscience·C M AtkinsJ D Sweatt
Jul 13, 1999·Neuron·S ImpeyD R Storm
Sep 11, 1999·Neuron·S T WongD R Storm
Jul 26, 2000·Bioelectrochemistry·H H MiaoF S Sheu
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·J H PakK P Huang
Jan 15, 2001·The Journal of Biological Chemistry·P ZanassiS Schinelli
Jan 9, 2001·Journal of Neurochemistry·J D Sweatt
Mar 30, 2001·The Journal of Biological Chemistry·Y ZhangZ Dong
Jun 22, 2001·FEBS Letters·S BapatJ A Post
Jul 20, 2001·Journal of Neurochemistry·T CrowJ T Neary
Jul 27, 2001·Journal of Cellular Physiology·L W LoD L Wang
Citations
Jun 2, 2005·Neuroscience Letters·Chenchen NiuQunyuan Xu
Jul 1, 1997·Mechanisms of Ageing and Development·I D LaviadaA Haro
Oct 27, 2010·Biochemistry·Xu WangJohn A Putkey
Nov 10, 2007·The Journal of Biological Chemistry·John A PutkeyQuinn K Kleerekoper
Nov 23, 2006·Antioxidants & Redox Signaling·Kenneth T Kishida, Eric Klann
Jul 24, 2010·Antioxidants & Redox Signaling·Cynthia A Massaad, Eric Klann
Apr 22, 2006·Journal of Neurosurgical Anesthesiology·Meng FanjunJi Fang
Jan 2, 2007·Journal of Neurosurgical Anesthesiology·Jun JiaJunfa Li
Aug 3, 2007·Learning & Memory·Freesia L HuangCatherine Boucheron
Aug 5, 2004·BMC Musculoskeletal Disorders·Martha H MeyerRalph A Meyer
May 17, 2007·International Journal of Biological Sciences·Nian-Lin Reena HanFwu-Shan Sheu
Aug 9, 2011·Neuroscience·M KvajoJ A Gogos
Dec 24, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Hlin KvartsbergKaj Blennow
Dec 4, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Partha MukhopadhyayM Michele Pisano
Aug 29, 2009·The EMBO Journal·Ling ZhongNashaat Z Gerges
Sep 3, 2003·Journal of Neurochemistry·Junfang WuFreesia L Huang
Nov 17, 2007·The European Journal of Neuroscience·Dilja D Krueger, Angus C Nairn
May 9, 2012·Journal of Neurochemistry·Gustavo P GuerraMaribel A Rubin
May 18, 2012·The Journal of Comparative Neurology·S GribaudoS De Marchis
Jan 5, 2011·The European Journal of Neuroscience·Ling ZhongNashaat Z Gerges
Jul 29, 2010·IUBMB Life·F Javier Díez-Guerra
Jul 1, 2014·Hippocampus·Amina ChaalalValérie Enderlin
May 11, 2006·Brain Research·Junfa LiLi Fang
Jul 8, 2008·Brain Research·Ling LiYumin Luo
Jul 11, 2006·Neuroscience Letters·Pradeep K ShuklaZaijie Jim Wang
Jun 27, 2006·European Journal of Pharmacology·Lei TangZaijie Jim Wang
Oct 11, 2005·Brain Research·Junfa LiLi Fang
Sep 27, 2005·Neuroscience Letters·Junfa LiLi Fang
Feb 20, 2007·Brain Research·Lei TangZaijie Jim Wang
Oct 21, 2015·Frontiers in Neuroscience·Kaj Blennow, Henrik Zetterberg
Sep 16, 2008·Neuropharmacology·Steven T SzaboJing Du
May 5, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Kaj BlennowLucilla Parnetti
Jul 21, 2004·The Journal of Biological Chemistry·Tara R GaertnerM Neal Waxham
Apr 13, 2011·Synapse·Sanders A McDougallCynthia A Crawford
Apr 28, 2018·Acta Neuropathologica·Erik PorteliusKaj Blennow
Jul 28, 2018·Journal of Internal Medicine·K Blennow, H Zetterberg
Nov 16, 2002·Blood·Dmitri V GnatenkoWadie F Bahou
May 7, 2020·The Journal of Biological Chemistry·Filip TrckaPetr Man
Mar 3, 2007·Journal of Neuroscience Research·Ping HuangJunfa Li
Mar 23, 2018·Journal of Alzheimer's Disease : JAD·Kaj Blennow, Henrik Zetterberg
Dec 10, 2019·Proteomics·Hyung W NamUrska Cvek
Oct 9, 2002·The Journal of Biological Chemistry·Elisabetta CianiAntonio Contestabile
May 24, 2006·World Journal of Gastroenterology : WJG·Ya-Jun WangShu-Wen Zhang
Feb 14, 2007·The Biochemical Journal·Irene Domínguez-GonzálezF Javier Díez-Guerra
Feb 1, 2021·The Journal of Biological Chemistry·Filip TrckaPetr Man
May 1, 2021·International Journal of Molecular Sciences·Simona GribaudoSilvia De Marchis