Attenuation of reperfusion injury by the antioxidant n-propyl gallate

Journal of Cardiovascular Pharmacology
A Bhatnagar

Abstract

We studied the effects of n-propyl gallate (n-PG) on Langendorff preparations of isolated rat hearts. Perfusion of the hearts with Krebs-Henseleit (KH) solution containing 20 microM n-PG did not cause a statistically significant change in either left ventricular systolic pressure (LVSP), end-diastolic pressure (LVEDP), developed pressure (LVDP), or heart rate (HR), indicating that n-PG has little acute myocardial toxicity. The effects of n-PG on the reperfused and ischemic myocardium were tested in hearts subjected to 15-min global P4 the ischemic hearts with KH buffer resulted in the recovery of the LVDP to 66 +/- 7% (mean +/- SEM, n = 11) and the recovery of the rate-pressure product (RPP) to 65 +/- 7% of their preischemic values. The LVEDP of the reperfused hearts was 30 +/- 5 mm Hg as compared with the preischemic LVEDP of 5.2 +/- 0.9 mm Hg. The difference between the coronary flow rate of the preischemic hearts (15.4 +/- 0.8 ml/min) and the reperfused hearts (13.9 +/- 0.9 ml/min) was not statistically significant (p > 0.05). Addition of n-PG, at the time of reperfusion, resulted in with KH buffer containing 20 microM n-PG had LVEDP of 6.2 +/- 0.4 mm Hg, and both LVDP and RPP recovered to 92 +/- 4% of the preischemic contro...Continue Reading

Citations

Dec 13, 2000·Experimental Gerontology·B VilleponteauJ Feng
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·S D NewcomerD W Zeh
Jun 6, 1998·The Journal of Biological Chemistry·S SrivastavaA Bhatnagar
Jan 29, 2008·The Journal of Biological Chemistry·Karin KaiserovaAruni Bhatnagar
Jan 11, 2005·The Journal of Pharmacy and Pharmacology·K KarthikeyanS Niranjali Devaraj
Mar 29, 2006·The Journal of Biological Chemistry·Karin KaiserovaAruni Bhatnagar
Feb 17, 2001·Journal of Applied Toxicology : JAT·A M Sciuto, T S Moran

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