Attenuation of reproductive dysfunction in diabetic male rats with timber cultured Antrodia cinnamomea ethanol extract

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Athira JohnsonZwe-Ling Kong

Abstract

Diabetes mellitus together with the oxidative stress affects the process of spermatogenesis and leads to male infertility. Antrodia cinnamomea (AC) is a mushroom found unique in Taiwan and commonly used for the treatment of several types of cancers and inflammatory disorders. This study was aimed to investigate the anti-oxidative and the ameliorative effects of Antrodia cinnamomea ethanol extract (ACEE) on reproduction dysfunction in male diabetic rats. The diabetic condition was induced by administrating the combination of streptozotocin (STZ) (65 mg/kg) and nicotinamide (NA) (230 mg/kg). Three different doses of ACEE were tested (385, 770, 1540 mg/kg) for 5 weeks. The results indicated that the ACEE improved STZ-NA induced hyperglycemia, oxidative stress, and insulin resistance. In addition to this, ACEE reduced the degree of lipid peroxidation, recovered the abnormal structure of the seminiferous tubules, and improved sperm parameters. Moreover, the DNA damages and mitochondrial membrane potential were improved in sperm. Our study confirmed that the ACEE has anti-inflammatory and ameliorative effects to prevent diabetes-induced male reproductive dysfunction.

References

Jan 1, 1987·Diabetes Care·R Vigneri, I D Goldfine
Aug 1, 1966·Analytical Biochemistry·Z A PlacerB C Johnson
Jan 1, 1984·Methods in Enzymology·H Aebi
Oct 18, 1995·Molecular and Cellular Biochemistry·R KakkarK Prasad
Feb 1, 1996·Journal of Pharmacological and Toxicological Methods·C M PalmeiraK B Wallace
Aug 31, 2001·Human Reproduction·E V YounglaiR F Casper
May 15, 2002·FEMS Microbiology Letters·I-Hung LeeMei-Kuang Lu
May 16, 2002·Journal of Agricultural and Food Chemistry·Tuzz-Ying Song, Gow-Chin Yen
Mar 5, 2003·Journal of Biochemical and Molecular Toxicology·A C MaritimJ B Watkins
Jul 2, 2003·Biological Trace Element Research·Katsuhiko YokoiForrest H Nielsen
Aug 5, 2004·Journal of Andrology·Joan BallesterJoan E Rodríguez-Gil
Feb 24, 2006·International Journal of Clinical Practice·E WrightL C Glass
Jun 30, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·J Thomas Sanderson
May 10, 2007·Developmental Biology·Rüdiger BehrKlaus H Kaestner
Aug 19, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Madamanchi Geethangili, Yew-Min Tzeng
Nov 19, 2009·International Journal of Andrology·J O'NeillC Mallidis
Feb 19, 2010·International Journal of Diabetes in Developing Countries·B AndalluN Ch Varadacharyulu
Feb 22, 2011·Natural Product Research·Ming-Der WuBor-Cheh Wang
May 24, 2012·Experimental Biology and Medicine·Tomasz Szkudelski
Jun 19, 2012·Acta Pharmacologica Sinica·Xin-ting WangXiao-dong Liu
Apr 30, 2013·North American Journal of Medical Sciences·Manjulata KumawatVijay Shankar
Jun 5, 2013·American Journal of Epidemiology·Setor K KunutsorJohn Walley
Dec 20, 2013·Systems Biology in Reproductive Medicine·Maria Inês SousaJoão Ramalho-Santos
Feb 8, 2014·International Journal of Molecular Medicine·Yanping CaoHuijun Duan
Oct 1, 2012·Journal of Traditional and Complementary Medicine·Yen-Wenn LiuLee-Yan Sheen
Mar 31, 2015·Asian Journal of Andrology·Guo-Lian DingHe-Feng Huang
Jul 2, 2015·World Journal of Diabetes·Akram T Kharroubi, Hisham M Darwish
Sep 30, 2015·Lipids in Health and Disease·Barry Sears, Mary Perry
Apr 6, 2016·Frontiers in Pharmacology·Chi Teng VongMaggie Pui Man Hoi
Nov 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohamed A DkhilAhmed E Abdel Moneim
Dec 13, 2016·The Biochemical Journal·Philip NewsholmePaulo Ivo Homem de Bittencourt
Apr 14, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Guang-Jiang ShiJian-Qiang Yu
May 10, 2017·Human Reproduction·Clara Helene GlazerElvira Vaclavik Bräuner
Dec 27, 2017·Acta histochemica·Temidayo S OmolaoyeStefan S du Plessis
Feb 28, 2018·Turkish Journal of Urology·Niyazi Küçük

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Citations

Apr 14, 2020·Journal of Food Biochemistry·Emmanuel Ayobami MakindeOpeyemi Joshua Olatunji
Dec 3, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Toyin Dorcas AlabiOluwafemi Omoniyi Oguntibeju

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