Attenuation of resting energy expenditure following hematopoietic SCT in children.

Bone Marrow Transplantation
Lori J BechardChristopher Duggan

Abstract

Children undergoing hematopoietic SCT (HSCT) typically receive parenteral nutrition (PN) due to gastrointestinal toxicities. Accurate determination of resting energy expenditure (REE) may facilitate optimal energy provision and help avoid unintended overfeeding or underfeeding. A multicenter, prospective cohort study of children undergoing allogeneic HSCT was performed, in which REE was measured by indirect calorimetry at baseline and twice weekly until 30 days after transplantation. Change in percent predicted REE over time from admission was analyzed using repeated measures regression analysis. In all, 26 children (14 females) with a mean (s.d.) age of 14.9 (4.2) years who underwent an HLA-matched sibling or unrelated donor transplantation were enrolled. Mean (s.d.) percent predicted REE at baseline was 92.4 (15.2). Baseline REE was highly correlated with lean body mass measured by dual energy X-ray absorptiometry (r=0.78, P<0.0001). REE decreased significantly over time, following a quadratic curve to a nadir of 79% predicted at 14 days post transplantation (P<0.001) and returned to near baseline by day 30. Children undergoing HSCT exhibit a significant reduction in REE in the early weeks after transplantation, a phenomenon ...Continue Reading

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Citations

Dec 24, 2013·Journal of Pediatric Gastroenterology and Nutrition·Debora DuroChristopher Duggan
Apr 25, 2013·Seminars in Pediatric Surgery·Brandy L Frost, Michael S Caplan
Jan 30, 2015·Pediatric Blood & Cancer·Lori J BechardChristopher Duggan
Jul 12, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Nilesh M MehtaCarol Braunschweig

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Clinical Trials Mentioned

NCT00115258

Software Mentioned

SAS
ESHA Food Processor
Nutrient Data Systems
Nutritionist Pro
SPSS PASW Statistics

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