PMID: 11907181Mar 22, 2002Paper

Attenuation of scopolamine-induced and age-associated memory impairments by the sigma and 5-hydroxytryptamine(1A) receptor agonist OPC-14523 (1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethanesulfonate)

The Journal of Pharmacology and Experimental Therapeutics
Katsura TottoriC Anthony Altar

Abstract

Sigma and 5-HT(1A) receptor stimulation can increase acetylcholine (ACh) release in the brain. Because ACh release facilitates learning and memory, we evaluated the degree to which OPC-14523 (1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethane sulfonate), a novel sigma and 5-HT(1A) receptor agonist, can augment ACh release and improve learning impairments in rats due to cholinergic- or age-related deficits. Single oral administration of OPC-14523 improved scopolamine-induced learning impairments in the passive-avoidance task and memory impairment in the Morris water maze. The chronic oral administration of OPC-14523 attenuated age-associated impairments of learning acquisition in the water maze and in the conditioned active-avoidance response test. OPC-14523 did not alter basal locomotion or inhibit acetylcholinesterase (AChE) activity at concentrations up to 100 microM and, unlike AChE inhibitors, did not cause peripheral cholinomimetic responses. ACh release in the dorsal hippocampus of freely moving rats increased after oral delivery of OPC-14523 and after local delivery of OPC-14523 into the hippocampus. The increases in hippocampal ACh release were blocked by the sigma recepto...Continue Reading

References

Oct 20, 1987·Brain Research·M FatranskáR Kvetnanský
Oct 7, 1967·Nature·J A Deutsch, K W Rocklin
Nov 1, 1971·Science·J A Deutsch
Feb 1, 1973·Japanese Journal of Pharmacology·H NabataK Takagi
May 1, 1984·Journal of Neuroscience Methods·R Morris
Jul 30, 1982·Science·R T BartusA S Lippa
Aug 7, 1981·Science·G E GibsonD J Jenden
Nov 1, 1995·Brain Research. Brain Research Reviews·A Blokland
Jan 1, 1997·Life Sciences·J H Growdon
Jun 1, 1997·Journal of Clinical Psychopharmacology·R Lane, D Baldwin
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE

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Citations

Jan 17, 2014·Experimental Brain Research·Mohammad SeyedabadiReza Rahimian
Apr 1, 2003·Expert Opinion on Investigational Drugs·Frank P BymasterPierre V Tran
Jun 10, 2015·Journal of Receptor and Signal Transduction Research·Colin G Rousseaux, Stephanie F Greene

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