Attenuation of the exercise pressor reflex. Effect of opioid agonist on substance P release in L-7 dorsal horn of cats

Circulation Research
A F MeintjesL B Wilson

Abstract

Using alpha-chloralose-anesthetized cats, we studied blood pressure and heart rate responses to static contraction and passive stretch of the triceps surae muscle before and after microdialyzing the mu-opioid agonist [D-Ala2]-methionine enkephalinamide (DAME, 200 mumol/L) into the L-7 dorsal horn of the spinal cord. In addition, we measured contraction-induced substance P release in the dorsal horn before and after drug delivery. After 92 +/- 3 minutes of dialyzing the opioid agonist, contraction-induced increases in mean arterial pressure and heart rate were attenuated from control values of 58 +/- 7 mm Hg and 17 +/- 3 beats per minute to postdrug values of 27 +/- 7 mm Hg and 10 +/- 2 beats per minute, respectively. A similar attenuation was observed for the passive muscle stretches after 97 +/- 5 minutes of dialysis (control, 38 +/- 4 mm Hg and 8 +/- 2 beats per minute; after drug, 23 +/- 4 mm Hg and 5 +/- 1 beats per minute). Prior microdialysis of naloxone (300 mumol/L), a mu-antagonist, blocked this effect, suggesting that the opioid agonist has a specific receptor action. Naloxone alone had no effect on the pressor or tachycardiac responses. The contraction-induced increase in substance P-like immunoreactivity was reduced...Continue Reading

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Citations

Dec 23, 1998·Neuroscience and Biobehavioral Reviews·A Ally
Apr 1, 1997·Brain Research. Brain Research Reviews·L B Wilson, G A Hand
Jan 1, 1996·Peptides·G A OlsonA J Kastin
Aug 14, 1999·Brain Research. Brain Research Protocols·H GustafssonE Brodin
Jun 15, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Hirotsugu TsuchimochiMarc P Kaufman
Aug 31, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Joel D TrinityRussell S Richardson
Dec 15, 2015·The Journal of Physiology·Thales C BarbosaAntonio C L Nobrega
May 3, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Han-Jun WangIrving H Zucker
Jan 18, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Juan A Estrada, Marc P Kaufman
Jan 31, 2020·Exercise and Sport Sciences Reviews·André L TeixeiraLauro C Vianna
Jul 14, 2020·Exercise and Sport Sciences Reviews·Markus AmannJoshua C Weavil
Dec 17, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Han-Jun WangIrving H Zucker
May 31, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Lisete C MicheliniAntonio C L Nóbrega
Sep 20, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Simranjit K SidhuMarkus Amann
Sep 2, 1998·The American Journal of Physiology·L B Wilson, G A Hand
Jun 11, 1999·The American Journal of Physiology·L B WilsonA D Crews

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