PMID: 2108844Apr 1, 1990

Attenuation of the metabisulfite-induced bronchoconstrictive response by pretreatment with cromolyn

M D McClellanR M Cherniack


In a retrospective analysis of 1,544 patients who underwent provocative challenge with metabisulfite at the National Jewish Center between 1983 and 1987, an abnormal airway response to metabisulfite was found in 52 patients, an incidence of 3.4 percent. There was no relationship between this abnormal airway responsiveness to metabisulfite and the degree of airway obstruction present, or the degree of airway reactivity as assessed by the response to inhaled bronchodilator or exercise testing. In a pilot study, we found that the administration of cromolyn sodium prior to metabisulfite challenge markedly attenuated the abnormal bronchoconstrictive response in nine of ten patients. We conclude that a metabisulfite-induced bronchoconstrictive response cannot be predicted on the basis of the degree of airway obstruction or airway reactivity and that pretreatment with cromolyn sodium may attenuate the abnormal response.


Nov 1, 1986·The American Journal of Medicine·R K BushW Busse
Jul 1, 1986·The Journal of Allergy and Clinical Immunology·R K BushW Busse
Jan 1, 1985·Chest·I L Bernstein
Jan 3, 1981·Lancet·M G HarriesT S Orr
Mar 1, 1983·The Journal of Allergy and Clinical Immunology·M P GriffinE R McFadden
May 1, 1983·The Journal of Allergy and Clinical Immunology·H J Schwartz
Aug 1, 1982·The Journal of Allergy and Clinical Immunology·G R Werth
Oct 22, 1982·JAMA : the Journal of the American Medical Association·F J Twarog, D Y Leung
Jul 1, 1981·The Journal of Allergy and Clinical Immunology·D D Stevenson, R A Simon
Mar 1, 1980·The Journal of Clinical Investigation·E C DealE R McFadden


Jan 5, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A YuengsrigulE Nussbaum
Jan 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·J C de Jongste
Sep 25, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H VallyV Madan

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