PMID: 9444989Jan 28, 1998Paper

Attenuation of the vaccine Oka strain of varicella-zoster virus and role of glycoprotein C in alphaherpesvirus virulence demonstrated in the SCID-hu mouse

Journal of Virology
Jennifer MoffatA M Arvin

Abstract

The SCID-hu mouse implanted with human fetal tissue is a novel model for investigating human viral pathogenesis. Infection of human skin implants was used to investigate the basis for the clinical attenuation of the varicella-zoster virus (VZV) strain, V-Oka, from which the newly licensed vaccine is made. The pathogenicity of V-Oka was compared with that of its parent, P-Oka, another low-passage clinical isolate, strain Schenke (VZV-S), and VZV-Ellen, a standard laboratory strain. The role of glycoprotein C (gC) in infectivity for human skin was assessed by using gC-negative mutants of V-Oka and VZV-Ellen. Whereas all of these VZV strains replicated well in tissue culture, only low-passage clinical isolates were fully virulent in skin, as shown by infectious virus yields and analysis of implant tissues for VZV DNA and viral protein synthesis. The infectivity of V-Oka in skin was impaired compared to that of P-Oka, providing the first evidence of a virologic basis for the clinical attenuation of V-Oka. The infectivity of V-Oka was further diminished in the absence of gC expression. All strains except gC-Ellen retained some capacity to replicate in human skin, but cell-free virus was recovered only from implants infected with P-O...Continue Reading

References

Aug 1, 1992·The Journal of Infectious Diseases·A A GershonS Silverstein
Oct 1, 1992·The Journal of Infectious Diseases·M H SawyerM R Wallace
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A E SearsB Roizman
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H KaneshimaJ M McCune
Jan 1, 1990·Advances in Experimental Medicine and Biology·P R KinchingtonW T Ruyechan
Sep 6, 1990·The New England Journal of Medicine·R MahalingamD Gilden
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K D CroenS E Straus
Jul 1, 1986·Journal of Medical Virology·T OzakiM Takahashi
Sep 1, 1986·The Journal of General Virology·A J Davison, J E Scott
Nov 1, 1981·Journal of Virology·S E StrausH A Smith
Feb 1, 1982·The Journal of Experimental Medicine·Y M Centifanto-FitzgeraldB Roizman
Aug 1, 1982·The Journal of Infectious Diseases·S Bogger-GorenP L Ogra
Oct 1, 1995·The Journal of Pediatrics·P R Krause, D M Klinman
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E S MocarskiH Kaneshima
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·Z ZhuA A Gershon
Jun 24, 1993·Nature·G M AldrovandiJ A Zack
Sep 1, 1996·Infectious Disease Clinics of North America·C Grose

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Citations

Jul 10, 1999·Immunological Reviews·A Abendroth, A Arvin
Mar 3, 2004·Journal of Virology·Shannon L TaylorJennifer F Moffat
Jul 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Armin BaikerAnn M Arvin
Apr 6, 2007·Journal of Virology·Kavitha GowrishankarAllison Abendroth
May 3, 2008·The Journal of Infectious Diseases·Anne A GershonMichael D Gershon
Apr 17, 2009·Journal of Virology·John E CarpenterCharles Grose
Nov 27, 2009·The Journal of General Virology·Sophia P PavlovaWalter Fuchs
Sep 17, 2011·Expert Review of Vaccines·Mark QuinlivanD Scott Schmid
Apr 2, 2014·Reviews in Medical Virology·Mark Quinlivan, Judy Breuer
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·J F MoffatA M Arvin
Jun 24, 2003·Reviews in Medical Virology·Nancy L Cole, Charles Grose
Apr 16, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·H M LilieM H Wolff
Dec 2, 2000·Nature Medicine·P R Krause, D M Klinman
Apr 2, 2004·Cellular Microbiology·Patricia G Spear
Jan 30, 2007·Veterinary Research·Benoît MuylkensEtienne Thiry
Jul 1, 2007·Pakistan Journal of Biological Sciences : PJBS·Sara GharaviFarzaneh Sabahi
Jun 8, 2012·Journal of Virology·Anca SelariuHua Zhu
May 20, 2014·Expert Review of Vaccines·William P Halford
Feb 11, 2014·Nature Reviews. Microbiology·Leigh ZerboniAnn M Arvin
Dec 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Erin M BuckinghamCharles Grose

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