PMID: 9551732Apr 29, 1998Paper

Attenuation of virus-induced airway dysfunction in rats treated with imiquimod

The European Respiratory Journal
J R StokesR F Lemanske

Abstract

Viral respiratory infections cause acute airway abnormalities consisting of inflammation and physiological dysfunction in both animals and humans. It is likely that inflammatory cell products, such as cytokines, contribute substantially to viral-induced airway dysfunction. We hypothesized that imiquimod, an immune response enhancing agent that induces interferon-alpha, would attenuate the development of airway dysfunction during acute viral illness in rats. Adult Brown Norway rats were inoculated with parainfluenza type 1 (Sendai) virus or sterile vehicle, and treated with either imiquimod or water. Respiratory system resistance (Rrs), arterial oxygen tension (Pa,O2), lung viral titres and bronchoalveolar lavage (BAL) leucocyte counts were measured in anaesthetized, paralysed, ventilated rats. Virus-infected, water-treated rats had a significant decrease in Pa,O2 and had significant increases in leucocyte count and Rrs when compared to both the virus-infected, imiquimod-treated, (Pa,O2, p = 0.03; leucocyte count, p = 0.02; and Rrs, p = 0.009) and noninfected, water-treated rats (Pa,O2, p = 0.007; leucocyte count, p = 0.001; and Rrs, p = 0.01). In addition, imiquimod suppressed BAL eosinophils in both virus-infected (p = 0.02) a...Continue Reading

Citations

Jul 20, 1999·International Journal of Immunopharmacology·R L MillerM A Tomai
Apr 15, 2003·Clinical Microbiology Reviews·Kelly J Henrickson
Oct 16, 2004·Expert Review of Anti-infective Therapy·Oliver KayserAlbrecht F Kiderlen
Dec 1, 2001·Expert Opinion on Biological Therapy·K N Masihi
Dec 2, 2010·European Journal of Pharmacology·Anna-Karin EkmanLars-Olaf Cardell
Nov 19, 2008·The Journal of Allergy and Clinical Immunology·John T Kelly, William W Busse
Nov 1, 2011·British Journal of Pharmacology·E H Kaufman, D B Jacoby
Dec 3, 2011·The Journal of Allergy and Clinical Immunology·David J JacksonSebastian L Johnston
Mar 21, 2001·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·H MochizukiA Morikawa
May 22, 2003·Dermatologic Clinics·Robert B Skinner

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