The cerebral cortex receives input from lower brain regions, and its function is traditionally considered to be processing that input through successive stages to reach an appropriate output. However, the cortical circuit contains many interconnections, including those feeding back from higher centres, and is continuously active even in the absence of sensory inputs. Such spontaneous firing has a structure that reflects the coordinated activity of specific groups of neurons. Moreover, the membrane potential of cortical neurons fluctuates spontaneously between a resting (DOWN) and a depolarized (UP) state, which may also be coordinated. The elevated firing rate in the UP state follows sensory stimulation and provides a substrate for persistent activity, a network state that might mediate working memory. Using two-photon calcium imaging, we reconstructed the dynamics of spontaneous activity of up to 1,400 neurons in slices of mouse visual cortex. Here we report the occurrence of synchronized UP state transitions ('cortical flashes') that occur in spatially organized ensembles involving small numbers of neurons. Because of their stereotyped spatiotemporal dynamics, we conclude that network UP states are circuit attractors--emergen...Continue Reading
Morphology and intracortical projections of functionally characterised neurones in the cat visual cortex
Spontaneous firing patterns and axonal projections of single corticostriatal neurons in the rat medial agranular cortex
Self-sustained asynchronous irregular states and Up-Down states in thalamic, cortical and thalamocortical networks of nonlinear integrate-and-fire neurons
Methods for predicting cortical UP and DOWN states from the phase of deep layer local field potentials
Impact of network topology on inference of synaptic connectivity from multi-neuronal spike data simulated by a large-scale cortical network model
An analysis of the transitions between down and up states of the cortical slow oscillation under urethane anaesthesia
Self-organized two-state membrane potential transitions in a network of realistically modeled cortical neurons
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Layer-specific excitatory circuits differentially control recurrent network dynamics in the neocortex
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Entorhinal cortex inhibits medial prefrontal cortex and modulates the activity states of electrophysiologically characterized pyramidal neurons in vivo
The thalamic low-threshold Ca²⁺ potential: a key determinant of the local and global dynamics of the slow (<1 Hz) sleep oscillation in thalamocortical networks
Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome
Theta and gamma power increases and alpha/beta power decreases with memory load in an attractor network model
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History-dependent excitability as a single-cell substrate of transient memory for information discrimination
Both neurons and astrocytes exhibited tetrodotoxin-resistant metabotropic glutamate receptor-dependent spontaneous slow Ca2+ oscillations in striatum
Scaling of topologically similar functional modules defines mouse primary auditory and somatosensory microcircuitry
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Visual experience-dependent maturation of correlated neuronal activity patterns in a developing visual system
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Chronic electrical stimulation homeostatically decreases spontaneous activity, but paradoxically increases evoked network activity
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Regional difference in stainability with calcium-sensitive acetoxymethyl-ester probes in mouse brain slices
Turning off cortical ensembles stops striatal Up states and elicits phase perturbations in cortical and striatal slow oscillations in rat in vivo
Accurate detection of low signal-to-noise ratio neuronal calcium transient waves using a matched filter
Classifying heterogeneity of spontaneous up-states: a method for revealing variations in firing probability, engaged neurons and Fano factor
Spontaneous neuronal burst discharges as dependent and independent variables in the maturation of cerebral cortex tissue cultured in vitro: a review of activity-dependent studies in live 'model' systems for the development of intrinsically generated bioelectric slow-wave sleep patterns
Optical monitoring of neuronal activity at high frame rate with a digital random-access multiphoton (RAMP) microscope
Sound-induced changes of infraslow brain potential fluctuations in the medial geniculate nucleus and primary auditory cortex in anaesthetized rats
Mode changes in activity of single neurons in anterior insular cortex across trials during multi-trial reward schedules
High-resolution multiple-unit EEG in cat auditory cortex reveals large spatio-temporal stochastic interactions
Effects of passive dendritic tree properties on the firing dynamics of a leaky-integrate-and-fire neuron
Contributions of NMDA receptors to network recruitment and rhythm generation in spinal cord cultures
Neural oscillations during non-rapid eye movement sleep as biomarkers of circuit dysfunction in schizophrenia
Mechanisms of Self-Sustained Oscillatory States in Hierarchical Modular Networks with Mixtures of Electrophysiological Cell Types
Optical probing of neuronal circuit dynamics: genetically encoded versus classical fluorescent sensors
Computational and in vitro studies of persistent activity: edging towards cellular and synaptic mechanisms of working memory
NMDA receptor-mediated epileptiform persistent activity requires calcium release from intracellular stores in prefrontal neurons
Storing cycles in Hopfield-type networks with pseudoinverse learning rule: admissibility and network topology
Heterogeneous effects of antiepileptic drugs in an in vitro epilepsy model--a functional multineuron calcium imaging study
Synaptic dynamics and neuronal network connectivity are reflected in the distribution of times in Up states
Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state
Intrinsic mode functions locate implicit turbulent attractors in time in frontal lobe MEG recordings
Neural codes in the thalamocortical auditory system: from artificial stimuli to communication sounds
Sevoflurane-induced loss of consciousness is paralleled by a prominent modification of neural activity during cortical down-states
Spontaneous activity governs olfactory representations in spatially organized habenular microcircuits
Formation and reverberation of sequential neural activity patterns evoked by sensory stimulation are enhanced during cortical desynchronization
Fast three-dimensional fluorescence imaging of activity in neural populations by objective-coupled planar illumination microscopy
Scale-free topology of the CA3 hippocampal network: a novel method to analyze functional neuronal assemblies
Stochastic emergence of repeating cortical motifs in spontaneous membrane potential fluctuations in vivo
Dynamics of self-sustained asynchronous-irregular activity in random networks of spiking neurons with strong synapses
Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states
Acetylcholine, GABA and neuronal networks: a working hypothesis for compensations in the dystrophic brain
Random Sampling with Interspike-Intervals of the Exponential Integrate and Fire Neuron: A Computational Interpretation of UP-States
Analysis of graph invariants in functional neocortical circuitry reveals generalized features common to three areas of sensory cortex
Slow Bursting Neurons of Mouse Cortical Layer 6b Are Depolarized by Hypocretin/Orexin and Major Transmitters of Arousal
Development of practical red fluorescent probe for cytoplasmic calcium ions with greatly improved cell-membrane permeability
Physiological consequences of selective suppression of synaptic transmission in developing cerebral cortical networks in vitro: differential effects on intrinsically generated bioelectric discharges in a living 'model' system for slow-wave sleep activity
Consistent estimation of complete neuronal connectivity in large neuronal populations using sparse "shotgun" neuronal activity sampling
Characterization and compensation of network-level anomalies in mixed-signal neuromorphic modeling platforms
Prolonged Intracellular Na+ Dynamics Govern Electrical Activity in Accessory Olfactory Bulb Mitral Cells
Spontaneous activations follow a common developmental course across primary sensory areas in mouse neocortex
Network activity influences the subthreshold and spiking visual responses of pyramidal neurons in the three-layer turtle cortex
Synchronized activation of striatal direct and indirect pathways underlies the behavior in unilateral dopamine-depleted mice
Percolation transition at growing spatiotemporal fractal patterns in models of mesoscopic neural networks
NeuroPath2Path: Classification and elastic morphing between neuronal arbors using path-wise similarity
Patterned activation of action potential patterns during offline states in the neocortex: replay and non-replay.
Computational simulation: astrocyte-induced depolarization of neighboring neurons mediates synchronous UP states in a neural network
Hysteresis, neural avalanches, and critical behavior near a first-order transition of a spiking neural network
Transient and Persistent UP States during Slow-wave Oscillation and their Implications for Cell-Assembly Dynamics
Highly Heterogeneous Excitatory Connections Require Less Amount of Noise to Sustain Firing Activities in Cortical Networks
Bistability and up/down state alternations in inhibition-dominated randomly connected networks of LIF neurons
Long-Term Effects of Early Life Seizures on Endogenous Local Network Activity of the Mouse Neocortex
Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing
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Noise-induced organized slow fluctuations in networks of neural areas with interarea feed-forward excitation and inhibition
Overproduction of Neurons Is Correlated with Enhanced Cortical Ensembles and Increased Perceptual Discrimination
Configuration and dynamics of dominant inspiratory multineuronal activity patterns during eupnea and gasping generation in vitro.
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