Atubular glomeruli in patients with chronic allograft rejection

Transplantation
M E PagtalunanT W Meyer

Abstract

Morphometric studies were performed in 15 patients with chronic renal allograft rejection. Biopsy cores were serially sectioned so that atubular glomeruli could be identified and volumes of individual glomeruli could be measured. Control tissue was obtained from 9 cadaver donors and 8 living donors. Serial sectioning revealed that atubular glomeruli were as common as sclerotic glomeruli in chronic rejection. The prevalence of atubular glomeruli averaged 18 +/- 15% (mean +/- SD) in recipients with chronic rejection, 2 +/- 2% in cadaver donors, and 1 +/- 3% in living donors (P<0.05, recipients vs. donor groups). In comparison, the prevalence of sclerotic glomeruli averaged 19 +/- 13%, 4 +/- 7%, and 7 +/- 10% in the three groups (P<0.05 recipients vs. donor groups). Atubular glomeruli exhibited reduced mean volume (3.1 +/- 0.9 x 10(6)micron(3) vs. 4.5 +/- 1.5 x lO(6)micron(3), atubular vs. open glomeruli in recipients, P < 0.05) but could not be distinguished from open glomeruli by their appearance on single sections. Recipients with chronic rejection exhibited tubular atrophy and interstitial fibrosis with an increase in the interstitial volume fraction to 51 +/- 14% as compared with 29 +/- 6% in cadaver donors and 17 +/- 2% in l...Continue Reading

References

Apr 1, 1992·Kidney International·P H LaneS M Mauer
Sep 1, 1991·Transplantation·N L TilneyD H Adams
Dec 1, 1990·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·N Marcussen
Dec 1, 1989·Kidney International·G A Tanner, A P Evan
Oct 1, 1989·Pathology, Research and Practice·A BohleG A Müller
Feb 1, 1988·Kidney International·B D MyersN S Coplon
Mar 1, 1988·Ultrastructural Pathology·P F ZhangW R Anderson
May 1, 1985·Kidney International·R K MaryniakM A Weiss
Jun 1, 1995·Kidney International·L C Paul
Jul 1, 1994·Kidney International·T H Hostetter
Feb 1, 1994·Journal of the American Society of Nephrology : JASN·A J MatasJ D Pirsch
Jun 1, 1993·Journal of the American Society of Nephrology : JASN·R A LafayetteT W Meyer
Mar 1, 1993·Kidney International·P H LaneS M Mauer
May 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B M Brenner, E L Milford

❮ Previous
Next ❯

Citations

May 1, 1997·The Journal of Laboratory and Clinical Medicine·E P CohenJ W Hopewell
Aug 24, 1999·Transplantation Proceedings·F J ShihC J Lee
May 28, 2010·Expert Reviews in Molecular Medicine·Wendy C Burns, Merlin C Thomas
Oct 10, 1998·Kidney International·M GandhiT W Meyer
Aug 19, 2004·Transplantation·Brian J NankivellJeremy R Chapman
Mar 15, 2006·Transplantation·Brian J Nankivell, Jeremy R Chapman
Feb 11, 2010·Transplantation·Allison B DartPatricia E Birk
Jan 15, 1997·The Journal of Clinical Investigation·M E PagtalunanT W Meyer
Jun 19, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kathryn E WhiteRudolf W Bilous
Aug 31, 2007·Kidney International·B A ThornhillR L Chevalier
Sep 11, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M AbecassisK P High
Jan 4, 2007·The American Journal of Pathology·Michael S ForbesRobert L Chevalier
Jan 18, 2008·Journal of the American Society of Nephrology : JASN·Robert L Chevalier, Michael S Forbes
Dec 25, 2015·Journal of the American Society of Nephrology : JASN·Koji TakaoriMotoko Yanagita
May 16, 2008·American Journal of Physiology. Renal Physiology·Kanishka MohibAnthony M Jevnikar
Mar 20, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Abhay N VatsMichael Mauer
Dec 15, 2005·American Journal of Physiology. Renal Physiology·Caigan DuAnthony M Jevnikar
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Wilhelm KrizJürgen Floege
Jun 26, 2001·Journal of the American Society of Nephrology : JASN·Basit JavaidTimothy W Meyer
Jun 23, 2000·Journal of the American Society of Nephrology : JASN·Maria Enrica PagtalunanTimothy W Meyer
Apr 24, 1999·Journal of the American Society of Nephrology : JASN·M E PagtalunanT W Meyer
Mar 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D L SuriT W Meyer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.