ATXN2L upregulated by epidermal growth factor promotes gastric cancer cell invasiveness and oxaliplatin resistance

Cell Death & Disease
Li LinWangjun Liao

Abstract

For gastric cancer (GC) control, metastasis and chemoresistance are the major challenges, accompanied with various stresses. Ataxin-2-like (ATXN2L) was discovered as a novel regulator of stress granules, yet its function in cancers remained unknown. Hence, we wanted to explore the functions of ATXN2L to see whether it participates in stress-related cancer malignant activities. Clinical follow-up was performed to see the impact of ATXN2L on GC patient survival. As a result, ATXN2L expression was upregulated in GC tissue and indicated adverse prognosis for overall survival and recurrence. In GC cells, ATXN2L expression was knocked down and functional experiments were performed. ATXN2L promoted GC cell migration and invasion via epithelial to mesenchymal transition, yet no influence on proliferation was detected by ATXN2L interference. When adding the chemotherapeutic agent oxaliplatin to induce stress, silencing ATXN2L sensitized GC cells to oxaliplatin. Interestingly, oxaliplatin was found to in turn promote ATXN2L expression and stress granule assembly. Then, two acquired oxaliplatin-resistant strains were generated by long-term oxaliplatin induction. The oxaliplatin-resistant strains presented with elevated ATXN2L levels, whil...Continue Reading

References

Jul 22, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anthony D YangLee M Ellis
Dec 21, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marie PrewettJames R Tonra
Jul 8, 2008·Cellular Signalling·David NonisGeorg Auburger
Aug 23, 2008·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Michèle SabbahChristian Gespach
Dec 5, 2012·PloS One·Christian KaehlerSylvia Krobitsch
Mar 5, 2013·International Journal of Cancer. Journal International Du Cancer·Lin WangWangjun Liao
Apr 15, 2014·Nucleic Acids Research·Christian KaehlerSylvia Krobitsch
Dec 9, 2014·Biochimica Et Biophysica Acta·Paul AndersonPavel Ivanov
Jul 15, 2017·Cell Death and Differentiation·Roberta CianfroccaAnna Bagnato

❮ Previous
Next ❯

Citations

Oct 30, 2019·Antioxidants·Eun-Kyung KimHo Hee Jang
Sep 19, 2019·Cancers·Yoojung KwonDooil Jeoung
Jul 24, 2020·International Journal of Molecular Sciences·Jana KeySuzana Gispert
Oct 2, 2019·European Journal of Pharmacology·Sepideh HamzehlouSeyed H Ghaffari
Jul 3, 2019·Neurological Research and Practice·Isabel Lastres-BeckerGeorg Auburger
Jan 31, 2021·Pharmaceuticals·Susie L Brown, Samantha Kendrick
Mar 30, 2021·Frontiers in Endocrinology·Weiwei Liang, Fangfang Sun
Oct 5, 2021·Frontiers in Cell and Developmental Biology·Mohammad Reza AsadiMaryam Rezazadeh

❮ Previous
Next ❯

Datasets Mentioned

BETA
GES-1
GSE36968
GSE51105
GSE35809
GSE14210
GSE15459
GSE22377
GSE29272

Methods Mentioned

BETA
flow cytometry
PCR
Assay

Software Mentioned

Pro Plus
Image

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.