Atypia of undetermined significance and nondiagnostic rates in The Bethesda System for Reporting Thyroid Cytopathology are inversely related

American Journal of Clinical Pathology
Paul A VanderLaanJeffrey F Krane

Abstract

There is substantial variation in the reported rates of different diagnostic categories in The Bethesda System for Reporting Thyroid Cytopathology (TBS). Specifically, the relationship between the nondiagnostic (ND) and atypia of undetermined significance (AUS) categories has not been closely examined previously. Data from published series in the literature and from 2 separate hospitals with more than 15,000 thyroid aspirates were reviewed. The AUS and ND rates were consistently negatively correlated when analyzed by year, aspirator, and cytologist. The strongest correlation was with cytologists (P < .0003). Absolute ND rates decreased by 1% for every 3.5% increase in AUS, implying the existence of a discrete population of cases that cytologists will classify as ND or AUS. As such, AUS and ND are not independent variables. Awareness of this relationship may be useful for laboratories and individual cytopathologists for refining the use of TBS.

References

Nov 6, 2009·Thyroid : Official Journal of the American Thyroid Association·Edmund S Cibas, Syed Z Ali
Nov 6, 2009·Thyroid : Official Journal of the American Thyroid Association·Constantine G A TheoharisDavid C Chhieng
Apr 17, 2010·American Journal of Clinical Pathology·Andrew A Renshaw
Dec 15, 2010·Cancer Cytopathology·John S Abele, Robert A Levine
Jan 18, 2011·The Journal of Clinical Endocrinology and Metabolism·Suk Kyeong KimNam Sun Paik

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Citations

Jan 24, 2013·European Journal of Endocrinology·Dorota Słowińska-KlenckaMariusz Klencki
Oct 16, 2015·Diagnostic Cytopathology·Betul CelikAziza Nassar
Apr 4, 2012·Clinical Endocrinology·Thomas J Sebo
Aug 14, 2013·Cytopathology : Official Journal of the British Society for Clinical Cytology·F PagniUNKNOWN San Gerardo Hospital collaborators group
Nov 10, 2013·Cancer Cytopathology·Marina ViveroJeffrey F Krane
May 28, 2014·Diagnostic Cytopathology·Kathriel J BristerHelen H Wang
Apr 8, 2017·Cancer Cytopathology·Marina ViveroJeffrey F Krane
Feb 26, 2013·The Journal of Clinical Endocrinology and Metabolism·Matthew T OlsonMartha A Zeiger
Jan 26, 2018·CA: a Cancer Journal for Clinicians·Sarah B Fisher, Nancy D Perrier

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