PMID: 44373Jan 1, 1979

Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent

M StanleyB M Cohen


The effects of the antipsychotic/antidepressant drug CI-686 on apomorphine- and amphetamine-induced stereotypies, dopamine metabolism, neuroleptic binding, and serum prolactin levels were determined. CI-686 displayed profiles of activity in each of these systems that differs markedly from those of other antipsychotics. CI-686's unique preclinical profile suggests a mechanism of action other than dopamine antagonism which could have implications regarding current thinking on the pathophysiology of schizophrenia.


Jan 7, 1977·European Journal of Pharmacology·S Wilk, M Stanley
Aug 15, 1977·European Journal of Pharmacology·M Stanley, S Wilk
Jun 1, 1977·Japanese Journal of Pharmacology·F HondaR Kato
May 1, 1975·Pharmakopsychiatrie, Neuro-Psychopharmakologie·H R BürkiT G White
Jan 1, 1974·Psychopharmacologia·J A ClemensB D Sawyer
Jul 30, 1966·Nature·A RANDRUP, I Munkvad
Jan 1, 1963·Acta Pharmacologica Et Toxicologica·A CARLSSON, M LINDQVIST
Jan 1, 1963·Acta Pharmacologica Et Toxicologica·A RANDRUPP UDSEN

Related Concepts

Antipsychotic Effect
Radioligand Assay
Stereotyped Behavior
Trebenzomine hydrochloride
Dopamine Antagonists

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