Abstract
Previous research has suggested an association between use of atypical antipsychotics and onset of diabetes mellitus. We sought to compare the incidence of new onset diabetes among patients receiving atypical antipsychotics, traditional antipsychotics or antidepressants. Retrospective cohort study of outpatients with claims for atypical antipsychotics (n = 10 265) compared to controls with claims for traditional antipsychotics (n = 4607), antidepressants (n = 60 856) or antibiotics (n = 59 878) in the administrative claims database of a large pharmaceutical benefit manager between June 2000 and May 2002. Main outcome measures were adjusted and unadjusted incidence rates of diabetes (new cases per 1000 per year) in a 12-month period, as measured using new prescriptions for antidiabetic drugs after a 6-month lead-in period. Annual unadjusted incidence rates of diabetes (new cases per 1000 per year) were 7.5 for atypical antipsychotics, 11.3 for traditional antipsychotics, 7.8 for antidepressants and 5.1 for antibiotics. In multivariable analyses, age, male sex and Chronic Disease Score were associated with greater odds of diabetes onset. There were no statistically significant differences in outcome between the atypical antipsych...Continue Reading
References
Feb 1, 1992·Journal of Clinical Epidemiology·M Von KorffK Saunders
Aug 1, 1995·Medical Care·D O ClarkG E Simon
Aug 1, 1995·Journal of Clinical Epidemiology·R TamblynJ Monette
Mar 1, 1997·The Journal of Clinical Psychiatry·A P PopliG E Jaskiw
Jul 22, 1998·The Journal of Clinical Psychiatry·S HäggR Dahlqvist
Nov 3, 1998·Biological Psychiatry·D A WirshingW C Wirshing
Feb 16, 1999·Schizophrenia Research·S LeuchtW Kissling
Sep 10, 1999·Psychosomatics·L E GoldsteinT A Stern
Sep 15, 1999·The Journal of Clinical Psychiatry·M SobelM A Franz
Jun 1, 2000·The American Journal of Psychiatry·D C HendersonD C Goff
Jul 25, 2000·Psychosomatics·P E CroarkinB K Bain
Aug 6, 2000·The Annals of Pharmacotherapy·T L BettingerM L Crismon
Sep 7, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·V RigalleauH Gin
Jul 20, 2001·Journal of Psychiatric Research·I D GlickR J Hu
Oct 30, 2001·American Journal of Epidemiology·S SchneeweissR J Glynn
Nov 28, 2001·JAMA : the Journal of the American Medical Association·E KollerP M Doraiswamy
Dec 26, 2001·Archives of General Psychiatry·B C LundS Arndt
Dec 19, 2001·The American Journal of Medicine·E KollerG Dubitsky
Apr 3, 2002·Archives of General Psychiatry·John W NewcomerGregg Selke
May 15, 2002·Journal of Clinical Psychopharmacology·Philip S WangJerry Avorn
May 30, 2002·Life Sciences·Martina C M Ryan, Jogin H Thakore
Aug 3, 2002·BMJ : British Medical Journal·Carol E KoroRobert W Buchanan
Nov 6, 2002·The Journal of Clinical Psychiatry·Frank D GianfrancescoHenry A Nasrallah
Jan 14, 2003·The Journal of Clinical Psychiatry·J Jaime CaroKimberly Robinson
Mar 26, 2003·Journal of Clinical Epidemiology·John B BuseLois Jovanovic
Citations
Jul 3, 2007·Social Psychiatry and Psychiatric Epidemiology·Carolyn HarleyWilliam Carson
Feb 1, 2012·Molecular Psychiatry·T CohenF Levine
May 25, 2006·Current Opinion in Psychiatry·Corrado Barbui, Mauro Percudani
Sep 19, 2009·Pharmacogenomics·Sara HaackJulia Kirchheiner
Mar 18, 2009·Journal of the American Pharmacists Association : JAPhA·L Douglas RiedJoel R McConkey
Nov 7, 2006·Forensic Science International : Synergy·Chris J House
Jun 1, 2005·Pharmacoepidemiology and Drug Safety·Muhammad Mamdani
Oct 9, 2007·Acta Psychiatrica Scandinavica·S LeuchtN Sartorius
Jan 20, 2012·British Journal of Clinical Pharmacology·Marie TournierHélène Verdoux
Aug 20, 2011·Psychiatry Investigation·Antonio Preti, Daniel R Wilson
Jun 15, 2016·Human Psychopharmacology·Edith M HeintjesRon M C Herings
Sep 2, 2011·Journal of Clinical Psychopharmacology·Geneviève LétourneauBéatrice Granger
Nov 11, 2006·International Journal of Geriatric Psychiatry·Lorenz HilwerlingStefan Georg Schröder
Apr 14, 2006·Current Opinion in Psychiatry·W Wolfgang Fleischhacker, Christian G Widschwendter
Jun 11, 2009·Journal of Clinical Psychopharmacology·Fiona Baroyant SalmasiSimin Dashti Khavidaki
Aug 8, 2014·Frontiers in Microbiology·Xueyan Shan, W Paul Williams
Jul 1, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Wolfgang AichhornJosef Marksteiner
Feb 18, 2011·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Jer-Hwa HsuPesus Chou
Jul 1, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Rolina D van GaalenDavid L Buckeridge
Sep 6, 2007·The Annals of Pharmacotherapy·Leslie L CitromeVicki Poole Hoffmann
Mar 28, 2021·Journal of Affective Disorders·Yuqing WangYili Wu
Mar 30, 2021·Frontiers in Psychiatry·Mark R Libowitz, Erika L Nurmi