Atypical arthritis due to combined hereditary hemochromatosis and active hepatitis C

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
Sara Zafar, Humeira Badsha

Abstract

A 51-year-old Caucasian female presented with asymmetric arthritis and a positive rheumatoid factor. She was initially treated for rheumatoid arthritis. However, she had features such as abnormal liver function tests and osteoarthritis in an unusual location, the metacarpophalangeal joint. Further workup revealed that the patient had active hepatitis C and hereditary hemochromatosis. Phlebotomy treatment initiation seemed to be associated with improvement in joint symptoms but, more importantly, may have prevented future risk of cirrhosis and hepatocellular cancer. Treatment for the hepatitis C may also be needed. Clinicians should look for underlying systemic illnesses leading to atypical inflammatory arthritis.

References

Jan 1, 1972·Seminars in Arthritis and Rheumatism·S de SèzeH Dorfmann
Dec 1, 1982·Arthritis and Rheumatism·H R Schumacher
Mar 1, 1994·Journal of Hepatology·D H Van ThielJ S Gavaler
Apr 1, 1996·Gastroenterology·C NiederauG Strohmeyer
Jun 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M YanoK Okuda
Apr 2, 1998·Hospital Practice·H R Schumacher
Jun 23, 1999·The American Journal of Medicine·S M McDonnellR Yip
May 10, 2000·Nature Genetics·C CamaschellaP Gasparini
Aug 5, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·H R Schumacher
Apr 4, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·Christine ChiavériniJean-Philippe Lacour
Oct 7, 2004·Clinics in Liver Disease·Christoph EisenbachWolfgang Stremmel
Mar 1, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ying ShanHerbert L Bonkovsky
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jean-Michel Pawlotsky
Dec 8, 2006·The New England Journal of Medicine·Jay H Hoofnagle, Leonard B Seeff

❮ Previous
Next ❯

Citations

Nov 28, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ishmael Kasvosve

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Rheumatology Reports
Emma Husar-MemmerJochen Zwerina
Annali italiani di medicina interna : organo ufficiale della Società italiana di medicina interna
A LonardoA Pietrangelo
© 2022 Meta ULC. All rights reserved