PMID: 6767878Jan 15, 1980Paper

Atypical bile acids (author's transl)

Klinische Wochenschrift
P Back

Abstract

The metabolism of bile acids in man is disturbed under the conditions of cholestasis. Besides of the main bile acids atypical bile acids can be found, which are mainly eliminated by renal excretion as sulphate esters and glucuronides. The pattern of urinary bile acids up to now renders no conclusions with respect to the underlying disease, although intrahepatic cholestasis seems to be in some way connected with disturbances in the metabolism of 3 beta-hydroxy-5-cholenoic acid, a bile acid, which exerts cholestatic effects by itself. The metabolites to be found seem to reflect a derepression of a genotypical synthesis program, which is not phenotypically apparent in healthy adults, but which may have been active during prenatal developmental stages of the liver.

References

Apr 1, 1976·The Journal of Clinical Investigation·S SheferE H Mosbach
Sep 1, 1977·Life Sciences·H EyssenG Janssen
Mar 1, 1975·The Journal of Clinical Investigation·I BjörkhemB Persson
Jan 30, 1976·European Journal of Clinical Investigation·W Fröhling, A Stiehl
Mar 14, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·P Back
Nov 1, 1973·Journal of Steroid Biochemistry·T Laatikainen, O Karjalainen
Jan 1, 1973·Hoppe-Seyler's Zeitschrift für physiologische Chemie·P Back, K Ross
Feb 1, 1974·European Journal of Clinical Investigation·A Stiehl
Jan 1, 1974·Acta paediatrica Scandinavica·A NormanO Ojamäe
Jan 1, 1968·Advances in Lipid Research·T Hoshita, T Kazuno
Nov 1, 1970·The American Journal of Medicine·G Fleischner, I M Arias
Jan 1, 1972·The Journal of Clinical Investigation·K E AndersonN B Javitt
Sep 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·R H Palmer
Jan 1, 1971·European Journal of Biochemistry·I Björkhem, J Gustafsson
May 1, 1968·The Journal of Clinical Investigation·N B Javitt, S Emerman
Nov 1, 1968·European Journal of Biochemistry·B P Lisboa, J A Gustafsson

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Citations

Jan 1, 1982·Scandinavian Journal of Gastroenterology·K SamuelsonA Norman
Aug 1, 1982·European Journal of Clinical Investigation·B Strandvik, S A Wikström

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