PMID: 6767878Jan 15, 1980Paper

Atypical bile acids (author's transl)

Klinische Wochenschrift
P Back


The metabolism of bile acids in man is disturbed under the conditions of cholestasis. Besides of the main bile acids atypical bile acids can be found, which are mainly eliminated by renal excretion as sulphate esters and glucuronides. The pattern of urinary bile acids up to now renders no conclusions with respect to the underlying disease, although intrahepatic cholestasis seems to be in some way connected with disturbances in the metabolism of 3 beta-hydroxy-5-cholenoic acid, a bile acid, which exerts cholestatic effects by itself. The metabolites to be found seem to reflect a derepression of a genotypical synthesis program, which is not phenotypically apparent in healthy adults, but which may have been active during prenatal developmental stages of the liver.


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Nov 1, 1973·Journal of Steroid Biochemistry·T Laatikainen, O Karjalainen
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Sep 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·R H Palmer
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