Atypical characteristics of frog and chick erythrocyte beta-adrenoceptors

European Journal of Pharmacology
K E Dickinson, S R Nahorski


The characteristics of beta-adrenoceptors on frog and chick erythrocytes have been compared to those present on rat erythrocyte, lung and cerebral cortical membranes. The receptors have been examined using the specific ligand [3H]dihydroalprenolol ([3H]DHA) with conventional filtration techniques. The equilibrium dissociation constant (KD) of [3H]DHA and the affinities of the non-selective beta-adrenoceptor antagonists propranolol, timolol and alprenolol, were very similar in all preparations examined. The relative order of potency of the catecholamines, isoprenaline greater than adrenaline greater than noradrenaline in rat lung, rat erythrocyte and frog erythrocyte; isoprenaline greater than noradrenaline greater than or equal to adrenaline in chick erythrocyte and rat cortex, suggest an overall beta 2-classification for the former and beta 1-classification of the latter tissues. However, the use of highly selective beta 1- or beta 2-agents and computer-assisted iterative curve fitting revealed that whereas rat cortex and lung possess both receptor subtypes (lung 80% beta 2, 20% beta 1: cortex 65% beta 1, 35% beta 2) only beta 2-sites were observed in rat erythrocytes. On the other hand, chick and frog erythrocytes possess a h...Continue Reading


Mar 4, 1985·Brain Research·G P RyanR A Davidoff
Sep 30, 1983·European Journal of Pharmacology·D Bojanic, S R Nahorski
Feb 27, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·A L KatynskiT W Moon
Jan 1, 1990·British Journal of Pharmacology·R A Challiss, C D Nicholson
May 1, 1988·The Journal of protozoology·F A CastrodadD M Phillips
Nov 1, 1993·Medicinal Research Reviews·J R Arch, A J Kaumann
Jan 1, 1982·British Journal of Clinical Pharmacology·H H HarmsJ Zaagsma
Sep 1, 1983·The Journal of Pharmacy and Pharmacology·B I CostinJ C Wanstall
Jul 1, 1985·The American Journal of Physiology·E E SusanniC Rosendorff

Related Concepts

ICI 118551, hydrochloride
Rana esculenta
August Rats
Norepinephrine Receptors
Beta-adrenergic receptor

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.