Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation

Molecular Autism
Brittany G TraversAndrew L Alexander

Abstract

The corpus callosum is the largest white matter structure in the brain, and it is the most consistently reported to be atypical in diffusion tensor imaging studies of autism spectrum disorder. In individuals with typical development, the corpus callosum is known to undergo a protracted development from childhood through young adulthood. However, no study has longitudinally examined the developmental trajectory of corpus callosum in autism past early childhood. The present study used a cohort sequential design over 9 years to examine age-related changes of the corpus callosum in 100 males with autism and 56 age-matched males with typical development from early childhood (when autism can first be reliably diagnosed) to mid-adulthood (after development of the corpus callosum has been completed) (3 to 41 years of age). The group with autism demonstrated a different developmental trajectory of white matter microstructure in the anterior corpus callosum's (genu and body) fractional anisotropy, which suggests atypical brain maturation in these regions in autism. When analyses were broken down by age group, atypical developmental trajectories were present only in the youngest participants (10 years of age and younger). Significant main...Continue Reading

References

Jan 22, 1990·The Journal of Comparative Neurology·A S Lamantia, P Rakic
Aug 1, 1995·Archives of Neurology·B EgaasO Saitoh
Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Feb 1, 1993·AJR. American Journal of Roentgenology·E CourchesneR Yeung-Courchesne
Aug 1, 1997·The American Journal of Psychiatry·J PivenS Arndt
Nov 4, 2000·Neurology·A Y HardanM S Keshavan
Jan 2, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T G ReeseV J Wedeen
Jan 28, 2004·Biological Psychiatry·Naama Barnea-GoralyAllan L Reiss
Oct 22, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew K BelmonteSara J Webb
Feb 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Setsu WakanaSusumu Mori
Apr 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lin-Ching ChangCarlo Pierpaoli
May 3, 2005·NeuroImage·Sheng-Kwei SongRegina C Armstrong
Sep 27, 2005·Journal of Neurosurgical Anesthesiology·Laurie B AmundsenGeraldine Dawson
Jan 7, 2006·Journal of Neuroscience Research·Laura A HarsanM Said Ghandour
Jul 13, 2006·Brain : a Journal of Neurology·Rajesh K KanaMarcel Adam Just
Aug 17, 2006·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Diane L WilliamsNancy J Minshew
Oct 7, 2006·NeuroImage·Andrew L AlexanderJanet E Lainhart
Mar 22, 2007·Nature Reviews. Neuroscience·Lynn K PaulElliott H Sherr
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew L AlexanderAaron S Field
Oct 9, 2007·NeuroImage·A GiorgioH Johansen-Berg
Aug 8, 2008·Experimental Brain Research·Giorgio M Innocenti
Dec 5, 2008·Journal of Clinical and Experimental Neuropsychology·H Julia HannayJack M Fletcher
Mar 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexander Leemans, Derek K Jones
Jun 6, 2009·Journal of Child Psychology and Psychiatry, and Allied Disciplines·C CheungG M McAlonan
Jun 6, 2009·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Adriana Rocha BritoCarlos Adolfo B Pinto Calçada
Sep 15, 2009·Biological Psychiatry·Thomas W Frazier, Antonio Y Hardan
Mar 10, 2010·NeuroImage·Antonio GiorgioHeidi Johansen-Berg
Aug 27, 2010·Autism Research : Official Journal of the International Society for Autism Research·Saudamini Roy DamarlaMarcel Adam Just

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Citations

Mar 30, 2016·Brain Connectivity·Douglas C DeanAndrew L Alexander
Oct 7, 2015·Frontiers in Psychiatry·Carmem GottfriedWilson Savino
Jul 30, 2015·Neurochemistry International·X Du, R A Hill
Aug 12, 2016·Human Brain Mapping·P Cédric M P KoolschijnHilde M Geurts
Dec 19, 2017·Autism Research : Official Journal of the International Society for Autism Research·Kristine McLaughlinJanet E Lainhart
Sep 25, 2017·Human Brain Mapping·Yi-Ling ChienSusan Shur-Fen Gau
Dec 20, 2017·Journal of Alzheimer's Disease : JAD·Patrick J LaoBradley T Christian
May 13, 2018·Brain Imaging and Behavior·Patrick J LaoBradley T Christian
May 28, 2019·Autism : the International Journal of Research and Practice·Samantha E Schulz, Ryan A Stevenson
Jul 23, 2020·American Journal of Speech-language Pathology·Kelly L Coburn, Diane L Williams
Feb 24, 2016·Journal of Autism and Developmental Disorders·V M VoganM J Taylor
Oct 9, 2019·Translational Psychiatry·Maryam KhanbabaeiNing Cheng
Jan 8, 2020·Brain Sciences·Christopher E BauerHawley E Montgomery-Downs
May 10, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Arash NazeriAristotle N Voineskos
Apr 29, 2021·Autism Research : Official Journal of the International Society for Autism Research·Shuxia YaoKeith M Kendrick

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Methods Mentioned

BETA
sedation

Software Mentioned

fMRIB FSL
DTI
Camino
ANTS
TK

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