Atypical effect of dopamine in modulating the functional inhibition of NMDA receptors of cultured retina cells

European Journal of Pharmacology
J L Do NascimentoF G De Mello

Abstract

Cultured retina cells released accumulated [3H]GABA (gamma-aminobutyric acid) when stimulated by L-glutamate, N-methyl-D-aspartate (NMDA) and kainate. In the absence of Mg2+, dopamine at 200 microM (IC50 60 microM), inhibited in more than 50% the release of [3H]GABA induced by L-glutamate and NMDA, but not by kainate. This effect was not blocked by the D1-like dopamine receptor antagonist, R-(+)-7-chloro-8-hydroxy-3-methyl- -phenyl-2,3,4,5-tetrahydro- H-3-benzazepine hydrochloride (SCH 23390), neither by haloperidol nor spiroperidol (dopamine D2-like receptor antagonists). The dopamine D1-like receptor agonist R(+)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,diol hydrochloride (SKF 38393) at 50 microM, but not its enantiomer, also inhibited the release of [3H]GABA induced by NMDA, but not by kainate; an effect that was not prevented by the antagonists mentioned above. (+/-)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin e hydrobromide (SKF 812497) had no effect. Neither 8BrcAMP (5 mM) nor forskolin (10 microM) inhibited the release of [3H]GABA. Our results suggest that dopamine and (+)-SKF 38393 inhibit the glutamate and NMDA-evoked [3H]GABA release through mechanisms that seem not to involve known dopa...Continue Reading

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Citations

Jun 18, 1999·British Journal of Pharmacology·N G CastroY Aracava
Feb 13, 2007·Brain Research Reviews·Ricardo A M ReisFernando G de Mello
Sep 8, 2006·Neurochemistry International·K C CalazaF G de Mello
Feb 28, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A M HerculanoJ L M Do Nascimento
Feb 28, 2006·Experimental Brain Research·K C CalazaP F Gardino
Jun 15, 2019·Cellular and Molecular Neurobiology·Adelaide da Conceição Fonseca PassosJosé Luiz Martins do Nascimento
Jul 31, 1999·Journal of Neurochemistry·M H VarellaR Linden
Feb 7, 2019·Journal of Neurophysiology·Reece E MazadeErika D Eggers
Sep 16, 2009·Neurochemistry International·Karen Renata Matos OliveiraJosé Luiz Martins do Nascimento

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