Atypical endometrial polyps and the incidence of endometrial cancer: a retrospective cohort study

BJOG : an International Journal of Obstetrics and Gynaecology
I S M JacobsN van Hanegem

Abstract

The aim of this study is to evaluate the incidence of endometrial carcinoma, proven after hysterectomy, in patients diagnosed with atypical endometrial hyperplasia confined to a polyp. A secondary aim is to establish factors associated with (pre-) malignant alterations in a polyp. A retrospective cohort study SETTING: Maastricht University Medical Centre (MUMC+) and Máxima Medical Centre in Eindhoven/Veldhoven (Máxima MC). Women who underwent a hysteroscopic polyp resection between 2008 and 2016. Patient characteristics and histopathology results of the polyp and, in case of a hysterectomy, the uterus were collected from patients' charts. A total of 1445 complete hysteroscopic polyp resections were included. Of those, 1390 polyps showed benign histopathology results, 39 polyps contained atypical hyperplasia and 16 polyps endometrial carcinoma. A hysterectomy was performed in 35 women who were diagnosed with atypical hyperplasia confined to a polyp after hysteroscopic polyp resection. Histopathologic assessment showed no additional (pre-)malignant changes of the endometrium in 12 women (30.8%), atypical hyperplasia in 11 women (28.2%) and endometrial carcinoma in 12 women (30.8%). None of the prognostic factors in consideration ...Continue Reading

References

Jan 11, 2003·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S F WongL C Tang
Apr 25, 2003·American Journal of Obstetrics and Gynecology·Luca SavelliLuciano Bovicelli
Apr 29, 2006·American Journal of Obstetrics and Gynecology·Federica ScriminSecondo Guaschino
Dec 25, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Khush Mittal, Deline Da Costa
Oct 22, 2008·American Journal of Obstetrics and Gynecology·Federica ScriminSecondo Guaschino
Nov 26, 2008·American Journal of Obstetrics and Gynecology·Enrico FerrazziMassimo Vignali
Dec 31, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E DreislerG Lose
Jul 28, 2009·American Journal of Obstetrics and Gynecology·Gabriela BaiocchiGian Carlo Di Renzo
Jun 10, 2010·Acta Obstetricia Et Gynecologica Scandinavica·Marit LiengErik Qvigstad
Jun 28, 2011·Annals of Surgical Oncology·Stephanie L WethingtonJason D Wright
Oct 24, 2012·Obstetrics and Gynecology·Cornelia L TrimbleUNKNOWN Society of Gynecologic Oncology Clinical Practice Committee
Nov 30, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·A OrboB Straume
May 17, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·P GambadauroR Torrejón
May 22, 2016·Clinical Radiology·UNKNOWN The Royal College Of RadiologistsUNKNOWN Administration Of Radioactive Substances Advisory Committee
Aug 9, 2016·Obstetrics and Gynecology·Simone R de RijkSjors F Coppus
May 10, 2017·International Journal of Surgery·Vasilios TanosStephan Gordts
Aug 15, 2017·Journal of Minimally Invasive Gynecology·Osnat ElyashivTally Levy
Dec 9, 2017·Climacteric : the Journal of the International Menopause Society·A GhoubaraA A A Ewies

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Citations

Oct 30, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Latife Atasoy KarakasAli Ayhan
Feb 24, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Cheong Lung Henry Wong, Po Lam So
Mar 24, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Salvatore Giovanni VitaleUNKNOWN From the Global Community of Hysteroscopy Guidelines Committee
Nov 14, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Laura DettiIrene Peregrin-Alvarez

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