Atypical eosinophilic angiocentric fibrosis on nasal septum

Auris, Nasus, Larynx
Noriko Watanabe, Kazuhiro Moriwaki

Abstract

Eosinophilic angiocentric fibrosis (EAF) is a rare benign condition of unknown aetiology and is most commonly found in the nasal septum and sinus mucosa. We report a case of EAF and present a review of the available literature. A 51-year-old man with progressive nasal obstruction was referred to our hospital. CT and MRI scans revealed a mass on the nasal septum; this was surgically excised. Histological analysis of the resected tumour showed an inflammatory infiltrate with a predominance of eosinophils present in fibrous matrix and absence of eosinophilic vasculitis and onion skinning. Histologically, it resembled granuloma faciale. However, our case was considered to be an EAF although eosinophilic vasculitis and onion skinning were not observed. This was because a cutaneous lesion was absent and the lesion was limited to the nasal septal mucosa.

References

May 1, 1983·American Journal of Otolaryngology·D K Holmes, W R Panje
Sep 19, 2000·The Journal of Laryngology and Otology·V MataiM Boxer
Feb 24, 2001·American Journal of Clinical Pathology·L D Thompson, D K Heffner
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Dec 25, 2003·Archives of Pathology & Laboratory Medicine·Sevgen Onder, Arzu Sungur
Apr 23, 2005·Acta Dermato-venereologica·Patricia A V ChinelliMarcello Nico

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Citations

Dec 1, 2008·Head and Neck Pathology·Reena JainCeleste N Powers
May 2, 2013·Case Reports in Otolaryngology·Yunchuan LiBin Hu
Jul 30, 2014·International Forum of Allergy & Rhinology·Christina H FangJean Anderson Eloy
Apr 17, 2015·Clinical Reviews in Allergy & Immunology·Hai LongQianjin Lu
Apr 12, 2017·The Annals of Otology, Rhinology, and Laryngology·Molly E Heft NealStella E Lee

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