PMID: 9169294May 1, 1997Paper

Atypical facial pain: a double-blind placebo-controlled crossover pilot study of subcutaneous sumatriptan

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
S D HarrisonM Harris

Abstract

A double-blind placebo-controlled crossover pilot study involving 19 patients was undertaken to evaluate the efficacy of subcutaneous sumatriptan, a selective 5-hydroxytryptamine (5-HT)-like receptor agonist, in the treatment of atypical facial pain (AFP). A reduction in total pain was found 120 min post injection in the sumatriptan group. Most patients, however, described the medication as ineffective overall, despite significant pain score reduction. The temporary improvement of pain scores with the active drug was thought to be too small to be of any clinical benefit, but suggests that vascular or neurogenic mechanisms may be involved in the aetiology of AFP. Sumatriptan is not an appropriate therapeutic option for patients with AFP, but could prove a valuable drug in experimental clinical pharmacology.

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Citations

Jun 1, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·D ColognoF d'Onofrio
Jan 25, 2002·The New England Journal of Medicine·Peter J GoadsbyMichel D Ferrari
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Jan 4, 2012·Oral Diseases·R BenolielE Eliav
Feb 1, 2012·Headache·Miles Steven EvansLouis S Premkumar
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Jun 22, 2016·Neurosurgery Clinics of North America·Joanna M Zakrzewska
Apr 21, 2017·Cephalalgia : an International Journal of Headache·Rafael Benoliel, Charly Gaul
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Oct 22, 2011·Expert Review of Neurotherapeutics·Mark ObermannZaza Katsarava
Apr 19, 2002·Brain : a Journal of Neurology·Manjit S Matharu, Peter J Goadsby
Feb 10, 2017·Physiological Reviews·Peter J GoadsbySimon Akerman

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