Atypical fibroxanthoma†

Journal of Surgical Case Reports
Luciano ZogbiAluísio Neutzling

Abstract

Atypical fibroxanthoma (AFX) is a rare skin neoplasm of low-grade malignancy and fibroblastic origin. AFX is a curable cutaneous disease and the diagnosis depends on knowledge of its clinical and histological features and combined immunohistochemistry markers. This study presents a case of a male patient, aged 90 years, presented with painless skin lesion in his ear. The lesion had been growing progressively for 2 months, measured ∼1.5 cm, ulcerated, fixed and firm. After a biopsy, the patient underwent a complete resection with adequate surgical margins and showed favorable evolution without complications or recurrence. The histopathological evaluation showed a poorly circumscribed ulcerated dermal nodule, mesenchymal proliferation, with pleomorphic spindle cells. There was infiltration of the deep dermis and subcutis, showing malignant features, but there was no invasion of cartilage. The immunohistochemical analysis confirmed the diagnosis of AFX.

References

Jun 8, 2010·The American Journal of Dermatopathology·Trevor W BeerPeter J Heenan
Jan 29, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Luciano J Iorizzo, Marc D Brown
Jun 15, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Aaron H J WithersSwee T Tan
Mar 23, 2012·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Elizabeth Chipp, Sukh Rayatt
Jan 19, 2013·Seminars in Diagnostic Pathology·Alejandro A Gru, Daniel J Santa Cruz

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Citations

Aug 13, 2015·Journal of Cutaneous Pathology·Juan C TardíoCarlos Santonja
Jul 25, 2019·The American Journal of Dermatopathology·Jasmine SalehBen J Friedman
May 16, 2019·Anais Brasileiros De Dermatologia·Esra SaracMustafa Ozdemir
Jan 1, 2019·Anais Brasileiros De Dermatologia·Esra SaracMustafa Ozdemir
May 12, 2021·Clinics in Dermatology·Shwetapadma Sahu, Gil Yosipovitch

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Methods Mentioned

BETA
biopsy

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