Jan 26, 2016

Atypical IκB proteins in immune cell differentiation and function

Immunology Letters
Michaela AnnemannIngo Schmitz

Abstract

The NF-κB/Rel signalling pathway plays a crucial role in numerous biological processes, including innate and adaptive immunity. NF-κB is a family of transcription factors, whose activity is regulated by the inhibitors of NF-κB (IκB). The IκB proteins comprise two distinct groups, the classical (cytoplasmic) and the atypical (nuclear) IκB proteins. Although the cytoplasmic regulation of NF-κB is well characterised, its nuclear regulation mechanisms remain marginally elucidated. However, work from recent years indicated that nuclear IκBs contribute significantly to the modulation of NF-κB-mediated transcription in the immune system. Here, we discuss the role of the atypical IκB proteins Bcl-3, IκBζ, IκBNS, IκBη and IκBL for the regulation of gene expression and effector functions in immune cells.

Mentioned in this Paper

Immune System
T-Lymphocyte
Immune Effector Cell
REL
Regulation of Biological Process
Transcription, Genetic
Inhibitors
Bcl-x protein
Gene Expression
Cell Differentiation Process

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