Jan 26, 2016

Atypical IκB proteins in immune cell differentiation and function

Immunology Letters
Michaela AnnemannIngo Schmitz


The NF-κB/Rel signalling pathway plays a crucial role in numerous biological processes, including innate and adaptive immunity. NF-κB is a family of transcription factors, whose activity is regulated by the inhibitors of NF-κB (IκB). The IκB proteins comprise two distinct groups, the classical (cytoplasmic) and the atypical (nuclear) IκB proteins. Although the cytoplasmic regulation of NF-κB is well characterised, its nuclear regulation mechanisms remain marginally elucidated. However, work from recent years indicated that nuclear IκBs contribute significantly to the modulation of NF-κB-mediated transcription in the immune system. Here, we discuss the role of the atypical IκB proteins Bcl-3, IκBζ, IκBNS, IκBη and IκBL for the regulation of gene expression and effector functions in immune cells.

Mentioned in this Paper

Immune System
Immune Effector Cell
Regulation of Biological Process
Transcription, Genetic
Bcl-x protein
Gene Expression
Cell Differentiation Process

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