Atypical language characteristics and trajectories in children with 22q11.2 deletion syndrome

Journal of Communication Disorders
E Van Den HeuvelI Zink

Abstract

22q11.2 deletion syndrome (22q11.2DS) is a genetic condition associated with a highly variable phenotypic expression. During childhood speech and language deficits are commonly observed. Findings of cross-sectional studies suggest syndrome-specific and changing language profiles, but a longitudinal approach to identify developmental changes is still lacking to date. The present study aimed to delineate language characteristics and trajectories by comparing the performance of Dutch-speaking school-aged children with 22q11.2DS (n = 18) to those of peers with idiopathic intellectual disability (IID, n  = 19) and to those of children with IID and comorbid autism spectrum disorder (IID + ASD, n = 23). The literature shows contradictory findings regarding language comprehension difficulties in children with 22q11.2DS, we focused on the receptive-expressive language discrepancy. Given their relative strength for verbal short-term memory (VSTM) tasks, a fine-grained error categorization was included to elucidate a possible influence of VSTM on the expressive language outcomes. Finally, we suggested that the inability of children with 22q11.2DS to use contextual information could interfere with morphosyntactic measures. All groups (22q1...Continue Reading

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Citations

Apr 24, 2020·New Directions for Child and Adolescent Development·Natalia RakhlinElena L Grigorenko
Jun 11, 2021·Journal of Developmental and Behavioral Pediatrics : JDBP·Nandini JhawarKevin M Antshel
Sep 28, 2021·The Clinical Neuropsychologist·Lauren Bush, Megan N Scott

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