Atypical large well-differentiated hepatocellular carcinoma with benign nature: a new clinical entity

Intervirology
Masatoshi Kudo

Abstract

Based on intranodular hemodynamic studies of nodular lesions associated with liver cirrhosis using computed tomography (CT) during arteriography, CT during arterial portography (CTAP) and angiography under ultrasonography, relatively large hepatocellular nodules with portal perfusion have been depicted. We report 17 such nodules in a total of 663 patients who underwent CTAP. Large well-differentiated hepatocellular carcinomas (HCCs) are characterized by the presence of intranodular portal perfusion even if they measure more than 2.5 cm in diameter. Such nodules display a benign nature clinically as well as pathologically. These nodules, called 'atypical large well-differentiated HCC or dysplastic nodules', show extremely slow growth. Pathological study showed extremely peculiar findings; the nodules consisted of homogeneously hyperplastic or well-differentiated HCC without the component of moderately or poorly differentiated HCC, and without fibrous capsules, vessel invasion or intrahepatic metastasis, all of which are commonly found in typical overt HCC. The incidence of such nodules is not rare; it was 2.6% (17/663) in our HCC patients who underwent CTAP over a period of 7 years. During the 7-year observation period, none of ...Continue Reading

Citations

Feb 20, 2009·Journal of Gastroenterology·Masatoshi Kudo
May 29, 2010·Journal of Cancer Research and Clinical Oncology·Xin-Yuan LuWen-Ming Cong
Apr 20, 2010·Expert Review of Anticancer Therapy·Anoop P Ayyappan, Kartik S Jhaveri
Nov 26, 2010·Magnetic Resonance Imaging Clinics of North America·Gaurav KhatriFrank H Miller
Jun 15, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luigi BolondiFabio Piscaglia
Jun 28, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shiro MiyayamaYoshiko Sudo
Sep 20, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Masayuki OkunoJean-Nicolas Vauthey

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