Atypical localization of myenteric neurons in the opossum lower esophageal sphincter

The American Journal of Anatomy
A SenguptaR K Goyal

Abstract

This study investigated sphincter-body differences in neuronal density and morphometry between the esophageal sphincter and body with a view to determining whether previously reported differences are authentic. The anatomical limits of the opossum lower esophageal sphincter were correlated with its physiological behavior by manometric demarcation. Following this, peeled whole mounts and paraffin and cryosections were used to study the morphology and morphometry of the esophageal myenteric plexus. Thirty animals were used and seven quantitated. The plexus of the esophageal body was located as usual in a plane between the longitudinal and circular muscle, which coincided with the plane of cleavage when these muscle layers were peeled apart for studying the plexus in whole mounts. In contrast, the plexus was located in several planes in the lower esophageal sphincter, which had no cleavage plane. Therefore, peeling the sphincter removes neurons and yields falsely low counts, making peel preparations of this region unsuitable for neuronal quantitation. In paraffin sections, the neuron density in the esophageal body 7 cm above the sphincter was 6,353 +/- 850/cm2, but decreased significantly to 2,254 +/- 353/cm2 at the 1-cm segment. ...Continue Reading

References

May 1, 1986·Stain Technology·R K Goyal, A Sengupta
Oct 1, 1974·The Journal of Clinical Investigation·S Rattan, R K Goyal
Apr 1, 1972·Journal of the History of Medicine and Allied Sciences·K D Keele
Feb 1, 1972·Journal of Clinical Pathology·G S McDonald, D O Hourihane
Apr 1, 1970·The Journal of Clinical Investigation·J Christensen

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Citations

Feb 1, 1988·Journal of the Autonomic Nervous System·A Sengupta, R K Goyal
Feb 10, 2004·Autonomic Neuroscience : Basic & Clinical·Menachem Hanani
Mar 27, 1997·The New England Journal of Medicine·R K Mittal, D H Balaban
Aug 2, 2001·Canadian Journal of Physiology and Pharmacology·Y Zhang, W G Paterson
Oct 24, 2007·Gastroenterology Clinics of North America·Larry MillerJames G Brasseur
Sep 9, 1998·The American Journal of Physiology·P T SzymanskiR K Goyal

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