Atypical manifestations of Epstein-Barr virus in children: a diagnostic challenge

Jornal de pediatria
Vasileios BolisSophia Tsabouri

Abstract

Clarify the frequency and the pathophysiological mechanisms of the rare manifestations of Epstein-Barr virus infection. Original research studies published in English between 1985 and 2015 were selected through a computer-assisted literature search (PubMed and Scopus). Computer searches used combinations of key words relating to "EBV infections" and "atypical manifestation." Epstein-Barr virus is a herpes virus responsible for a lifelong latent infection in almost every adult. The primary infection concerns mostly children and presents with the clinical syndrome of infectious mononucleosis. However, Epstein-Barr virus infection may exhibit numerous rare, atypical and threatening manifestations. It may cause secondary infections and various complications of the respiratory, cardiovascular, genitourinary, gastrointestinal, and nervous systems. Epstein-Barr virus also plays a significant role in pathogenesis of autoimmune diseases, allergies, and neoplasms, with Burkitt lymphoma as the main representative of the latter. The mechanisms of these manifestations are still unresolved. Therefore, the main suggestions are direct viral invasion and chronic immune response due to the reactivation of the latent state of the virus, or even v...Continue Reading

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Citations

Jun 20, 2020·Journal of Medical Virology·Ying Yang, Feng Gao
Jul 27, 2017·Arquivos de neuro-psiquiatria·Rodolfo Mendes QueirozRafael Gouvêa Gomes de Oliveira
Jan 30, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Gustavo Magno Baldin TigumanTais Freire Galvao
Apr 22, 2019·BMJ Case Reports·Inusha PanigrahiRaja Ashok Koganti
Mar 22, 2020·Pathogens·Mai Abdel Haleem AbuSalahChan Yean Yean
Oct 14, 2020·The Journal of International Medical Research·Yanming WuLei Zhang
Nov 10, 2020·BioMed Research International·Jean de Melo SilvaGemilson Soares Pontes

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