PMID: 11467485Jul 27, 2001

Atypical membranoproliferative glomerulonephritis in a cat

Veterinary Pathology
K InoueK Shirota

Abstract

Membranoproliferative glomerulonephritis was observed in a 2-year-old male Japanese domestic cat with clinical renal failure. In the glomeruli, moderate mesangial hypercellularity with an increased mesangial matrix and thickening of the capillary walls were prominent. In addition, frequent duplication of the capillary walls, splitting, and spike formation were observed in the glomerular basement membrane. Granular cat IgG and complement component deposition were detected globally along the glomerular capillary walls and in the mesangium. Transmission electron microscopy revealed dense deposits in the subendothelial and subepithelial regions and the mesangium. Mesangial interposition was also observed. These glomerular lesions are also found in humans with membranoproliferative glomerulonephritis type III, which has not been reported in animals.

References

Mar 1, 1979·Veterinary Pathology·D O Slauson, R M Lewis
Dec 1, 1982·Nihon juigaku zasshi. The Japanese journal of veterinary science·T HayashiK Fujiwara
Mar 1, 1995·The Journal of Clinical Investigation·K HøgåsenM Harboe

Citations

Sep 9, 2010·The Journal of Veterinary Medical Science·Junichi KamiieKinji Shirota
Jan 6, 2009·The Journal of Veterinary Medical Science·Tomoko AsanoKinji Shirota

Related Concepts

Biopsy
Cat Diseases
Felis catus
Cytochemistry
Kidney Glomerulus
Electron Microscopy
Membranoproliferative Glomerulonephritis, Type II

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