Atypical meningioma: progression-free survival in 161 cases treated at our institution with surgery versus surgery and radiotherapy

Journal of Neuro-oncology
Waseem MasalhaJuergen Grauvogel

Abstract

Although atypical meningioma recurs frequently in spite of total resection and/or radiotherapy, no consensus on optimal adjuvant management was found. However, several retrospective studies analysed the additional effect of adjuvant radiotherapy in atypical meningioma with inconsistent results. Therefrom, the purpose of this study was to evaluate prognostic factors influencing the recurrence/progression and progression-free survival (PFS) rates of atypical meningioma, particularly focused on the role of postoperative adjuvant radiotherapy. Between February 2001 and March 2015, 161 atypical meningioma resections were performed in our Department of Neurosurgery, of which, 128 cases underwent surgical treatment alone and 33 cases underwent surgery and radiotherapy. Kaplan-Meier analysis was used to provide median point estimates and PFS rates. The Cox-regression model was used in the univariate and multivariate analysis to identify significant factors associated with treatment. The extent of resection (Simpson grade I and II) significantly influenced the risk of recurrence (hazard ratio = 1.8, CI (95%) 1.3-2.6, p-value = 0.0004). There was no significant benefit for progression-free survival after adjuvant radiotherapy (hazard rat...Continue Reading

References

Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·D SIMPSON
Sep 8, 2005·Neurosurgery·Ashok Modha, Philip H Gutin
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Jun 30, 2009·Journal of Neuro-oncology·Anne DurandJacques Guyotat
Aug 31, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kyungil JoJong Hyun Kim
Oct 27, 2011·The Oncologist·Santosh SarafJ Lee Villano
Jan 31, 2012·Clinical Neurology and Neurosurgery·Marko AndricAndrew Hunn
Jul 23, 2013·World Neurosurgery·Ahmed ZaherSylvia A Ashamallah
Aug 21, 2013·Journal of Neuro-oncology·Hae Jin ParkHee-Won Jung
Dec 3, 2013·Neurosurgical Focus·Kangmin D LeeChristopher M McPherson
Apr 4, 2014·Neuro-oncology·Gurvinder KaurAndrew T Parsa
Dec 24, 2014·World Neurosurgery·Shaakir HasanRicardo J Komotar
Jun 4, 2015·World Neurosurgery·Xiaoyu CaoJunting Zhang
Oct 1, 2015·Neurosurgery·Or Cohen-InbarJason P Sheehan
Jan 18, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Michael D JenkinsonMohsen Javadpour
Mar 30, 2016·Acta neurochirurgica·Charles Champeaux, Laurence Dunn
Jul 30, 2016·Acta neurochirurgica·Toshiki EndoTeiji Tominaga
Sep 10, 2016·Journal of Neurosurgery·Hilary P BagshawDennis C Shrieve
Mar 25, 2017·Journal of Neurosurgery·Or Cohen-InbarJason P Sheehan
Jul 21, 2017·Journal of Neurological Surgery. Part B, Skull Base·Tamer RefaatJohn A Kalapurakal

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Citations

Sep 29, 2018·Journal of Neurosurgery·José Pedro LavradorRanjeev Bhangoo
May 31, 2019·Acta neurochirurgica·Eileen Maria Susanne StreckertBenjamin Brokinkel
Jan 5, 2020·Journal of Neuro-oncology·Naureen KericFlorian Ringel
Jan 17, 2019·Acta neurochirurgica·Ole Solheim
Apr 2, 2020·Journal of Neuropathology and Experimental Neurology·Adele FioravanzoValeria Barresi
Mar 20, 2018·Neurosurgical Review·Benedito Jamilson Araújo PereiraSuely Kazue Nagahashi Marie
Jul 12, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P D Delgado-López, E M Corrales-García
Feb 27, 2021·Journal of Neuro-oncology·Ansley UnterbergerIsaac Yang
Apr 13, 2021·Journal of Neurological Surgery. Part A, Central European Neurosurgery·Meike UnteroberdörsterDaniela Pierscianek
Jun 3, 2021·British Journal of Neurosurgery·Mônica Schuring-PereiraRuud Wiggenraad
Aug 7, 2021·Journal of the Neurological Sciences·Ansley UnterbergerIsaac Yang
Aug 12, 2021·Cancer Management and Research·Haibo TengJianguo Xu
Aug 11, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Mustafa GüdükM Necmettin Pamir
Aug 11, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Mustafa GüdükM Necmettin Pamir

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