Atypical moles in a patient undergoing chemotherapy with oral 5-fluorouracil prodrug

The British Journal of Dermatology
S Fukushima, N Hatta

Abstract

We present a patient with multiple pigmented lesions on the palms, soles, oral mucosa and nails after chemotherapy with oral 5-fluorouracil (5-FU) prodrug. Dermoscopically, most of the macules showed similar features, with pigmentation present predominantly on the crista superficialis, while a large, dark macule also showed pigmentation along the sulcus superficialis with irregular hyperpigmentation and depigmentation, suggesting malignancy. However, histologically, both types of lesion showed basal hyperpigmentation and the presence of a small number of large atypical melanocytes. We diagnosed these lesions as pigment flecks induced by 5-FU, and the pigmented lesions gradually diminished after the cessation of chemotherapy. Our findings suggested that immunosuppression and 5-FU led to the development of the atypical pigmented lesions.

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Citations

Jun 6, 2009·American Journal of Clinical Dermatology·Guillermo VillalónEsperanza Jordá
Mar 8, 2013·Annales de dermatologie et de vénéréologie·V SibaudC Robert
Jun 19, 2012·Journal of the American Academy of Dermatology·Keith Duffy, Douglas Grossman
Jun 18, 2011·Journal of the American Academy of Dermatology·José Bernabeu-WittelJulián Conejo-Mir
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Dec 24, 2010·The Journal of Dermatology·Miki Tanioka
Jun 1, 2016·Journal of the American Academy of Dermatology·Benjamin M PerryR John Young
Mar 31, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·G-Y Chu, C-Y Wu
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Feb 6, 2009·Melanoma Research·Edoardo ZattraMauro Alaibac
Oct 27, 2017·Journal of Cutaneous Pathology·Kelly A HaeuslerScott R Dalton

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