Atypical myopathy in Père David's deer (Elaphurus davidianus) associated with ingestion of hypoglycin A

Journal of Animal Science
Carolin BunertAnnette Liesegang

Abstract

From 2004 until 2016, 21 Père David's deer (Elaphurus davidianus) have died for unknown reason at Zoo Duisburg. These deer, also known as milu, have succumbed from a myopathy that occurred seasonally in autumn and in spring. The clinical signs shown by the animals closely resembles those of a disease called equine atypical myopathy (EAM), which is formerly known in horses. The cause for EAM in Europe was found in the ingestion of hypoglycin A, contained in samaras and seedlings of the sycamore maple tree (Acer pseudoplatanus). To test the hypothesis that the mortality of milus was caused by ingestion of hypoglycin A, 79 sera from all zoos and wildlife parks that have kept milus in Germany and Austria, including 19 diseased and 60 healthy animals, were used. Selected biochemical values and additionally hypoglycin A, methylenecyclopropyl acetic acid-carnitine (MCPA-carnitine), and acylcarnitines, which have been found in horses suffering from EAM, were determined. The results showed greater values of serum activities of creatine kinase (P < 0.001) and aspartate aminotransferase (P < 0.001) in diseased milus comparing to healthy ones confirming a myopathy in affected animals. Moreover, hypoglycin A and MCPA-carnitine were found in...Continue Reading

References

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Citations

Feb 28, 2020·Animals : an Open Access Journal From MDPI·Dominique-Marie VotionPascal Gustin
Mar 7, 2021·Journal of Veterinary Internal Medicine·Sonia González-MedinaRichard J Piercy
Jun 8, 2021·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Manuela HirzChristiane Herden
Jun 3, 2021·Toxins·Mandy BochniaAnnette Zeyner

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