Atypical neuroleptics clozapine and thioridazine enhance amphetamine-induced stereotypy

Pharmacology, Biochemistry, and Behavior
A Robertson, C MacDonald

Abstract

The effects of the atypical neuroleptics clozapine and thioridazine and the typical neuroleptic pimozide on amphetamine-induced behavior were examined. Pimozide, as expected, blocked both amphetamine-induced locomotion and stereotypy. Thioridazine and clozapine antagonized the increases in locomotion produced by amphetamine, but produced increases in amphetamine-induced stereotypy and lowered the threshold dose for stereotypy. It is suggested that the increased stereotypy might partly account for the decreased locomotion, and that this might be a primary effect of these atypical neuroleptics. The data would also suggest that the use of amphetamine-induced stereotypy as a model for psychosis is inappropriate, as clozapine and thioridazine, which enhance stereotypy, are antipsychotic.

References

Jun 11, 1979·Life Sciences·C J Niemegeers, P A Janssen
Feb 1, 1974·European Journal of Pharmacology·B Costall, R J Naylor
Sep 5, 1973·Nature: New Biology·T J Crow, C Gillbe
Nov 1, 1972·Journal of the Neurological Sciences·H L KlawansW J Weiner
May 1, 1980·The Journal of Pharmacy and Pharmacology·U M Al-Shabibi, N S Doggett
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·R MorgensternW Oelssner
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·L R Hedley, M B Wallach
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·L Kokkinidis, H Anisman
Jun 21, 1974·Science·S H SnyderD Greenberg

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Citations

Oct 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·C F Saller, A I Salama
Jan 1, 1990·Journal of Neural Transmission. General Section·P I TiedtkeW J Schmidt
Jan 1, 1992·Journal of Neural Transmission. General Section·D C Hoffman
Jan 1, 1992·Journal of Neural Transmission. General Section·S Behrens, W F Gattaz
Jan 1, 1994·Journal of Neural Transmission. General Section·W F GattazS Behrens
Jan 1, 1987·Journal of Neural Transmission·J A GrebbW J Freed
Mar 1, 1996·Psychopharmacology·B J Kinon, J A Lieberman
Feb 12, 1985·European Journal of Pharmacology·A Robertson, C MacDonald
Sep 1, 1994·European Journal of Pharmacology·K K de BeltránA R Cools
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·G D Anderson, G V Rebec
May 1, 1987·Pharmacology, Biochemistry, and Behavior·J L HowardK W Rohrbach
Nov 1, 1988·Pharmacology, Biochemistry, and Behavior·J T Tschanz, G V Rebec
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·E A LohD C Roberts
Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·A RobertsonC MacDonald
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·M E FrittsL Morris
Nov 14, 1997·Neuroscience and Biobehavioral Reviews·S A JosselynR J Beninger
Sep 13, 2014·Current Behavioral Neuroscience Reports·Alexandra D ForrestSteven J Siegel
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·J L HaraczG V Rebec
Feb 11, 1999·The Annals of Pharmacotherapy·J S MarkowitzT R Moore

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