PMID: 26350337Sep 10, 2015Paper

Atypical Neurotransmitters and the Neurobiology of Depression

CNS & Neurological Disorders Drug Targets
Samia Regiane JocaGregers Wegener

Abstract

Since the first report that the mechanism of action of antidepressants involves the facilitation of monoaminergic neurotransmission in the brain in the 1960s, the leading hypothesis about the neurobiology of depression has been the so called "monoaminergic hypothesis". However, a growing body of evidence from the last two decades also supports important involvement of non-monoaminergic mechanisms in the neurobiology of depression and antidepressant action. The discovery of nitric oxide (NO) and endocannabinoid signaling in the brain during the 1990s challenged the wellestablished criteria of classical neurotransmission. These transmitters are synthesized and released on demand by the postsynaptic neurons, and may act as a retrograde messenger on the presynaptic terminal, modulating neurotransmitter release. These unconventional signaling mechanisms and the important role as neural messengers have classified NO and endocannabinoids as atypical neurotransmitters. They are able to modulate neural signaling mediated by the main conventional neurotransmitters systems in the brain, including the monoaminergic, glutamatergic and GABAergic signaling systems. This review aims at discussing the fundamental aspects of NO- and endocannabin...Continue Reading

Citations

Feb 2, 2018·Acta Neuropsychiatrica·Vitor Silva Pereira, Vinícius Antonio Hiroaki-Sato
Feb 5, 2019·Phytotherapy Research : PTR·Palloma de A S HocayenRoberto Andreatini
Jun 23, 2020·Expert Opinion on Drug Discovery·George KonstantakopoulosPanayiota G Michalopoulou
Nov 22, 2018·Frontiers in Cellular Neuroscience·Lijuan ZhangZili You
Nov 11, 2020·The European Journal of Neuroscience·Izaque de Sousa MacielSâmia R L Joca
Jul 31, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·B DrukarchM M M Wilhelmus

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