Abstract
We describe a unique case of atypical natural killer (NK)-cell proliferation likely related to gluten sensitivity, mimicking NK-cell lymphoma. The patient, a 32-year-old man, has had persistent multiple erythematous bull-eye lesions in the stomach, small bowel, and large bowel for 3 years. Histologically, the lesions were well circumscribed and relatively superficial, composed of atypical medium-sized to large-sized lymphocytes with slightly irregular nuclear contours, a dispersed chromatin pattern, and clear cytoplasm. Immunohistochemistry and flow cytometry showed that the cells were NK cells expressing CD56 (aberrantly bright), T-cell intracellular antigen (TIA)-1, cytoplasmic CD3, and CD94, but not surface CD3, with bright aberrant expression of CD7 and a lack of other NK cell-associated markers. Polymerase chain reaction for rearrangement of the T-cell receptor-gamma chain gene showed no evidence of a clonal T-cell population, and in situ hybridization for Epstein-Barr virus encoded RNA was negative. There was no evidence of the involvement of peripheral blood or bone marrow. Although a diagnosis of extranodal NK/T-cell lymphoma was considered because of the atypical morphology and immunophenotypic aberrancy, no chemothera...Continue Reading
References
Jul 1, 1992·Human Pathology·K F WongM M Cheung
Jun 23, 1990·Lancet·S O'MahonyA Ferguson
Jan 1, 1995·Bulletin du cancer·P Biron, J P Droz
Jan 1, 1995·Cancer·T C GreinerE S Jaffe
Sep 1, 1994·The American Journal of Surgical Pathology·J K ChanV W Ma
May 1, 1993·Gastroenterology·E Arranz, A Ferguson
Jan 1, 1996·The American Journal of Surgical Pathology·E S JaffeF C Ho
Feb 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J GaleD H Wright
Aug 30, 2000·Lancet·C CellierN Brousse
Mar 22, 2001·Histopathology·P M KluinS Pileri
Jul 13, 2001·American Journal of Clinical Pathology·F VegaR Luthra
Sep 21, 2001·European Journal of Gastroenterology & Hepatology·S C ChoiD F Evans
Mar 21, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Elaine S Jaffe
Nov 5, 2002·The American Journal of Pathology·Andreas ZettlAndreas Chott
Mar 22, 2003·British Journal of Haematology·William G MoriceCurtis A Hanson
Jun 15, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Siok Bian NgIvy Sng
Dec 4, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Francisco VegaJeffrey L Jorgensen
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Mar 31, 2005·British Journal of Cancer·J LeeK Park
Citations
Sep 1, 2012·Journal of Hematopathology·Falko FendChrister Sundström
Oct 6, 2011·Archives of Pathology & Laboratory Medicine·Jerome S Burke
Jun 9, 2011·Leukemia & Lymphoma·Joji YamamotoHideo Harigae
Jan 21, 2014·Human Pathology·Vasiliki LeventakiFrancisco Vega
Jan 29, 2014·Seminars in Hematology·Ritsuro Suzuki
Oct 19, 2010·Annals of Diagnostic Pathology·Michele K McElroyNoel Weidner
Sep 14, 2010·Journal of Immunological Methods·Francisco Leon
Nov 14, 2014·Pathology·Shih-Sung Chuang
Sep 11, 2010·Blood·Kengo TakeuchiKazuo Oshimi
Oct 23, 2010·Blood·Adnan MansoorElaine S Jaffe
Jun 30, 2016·Hematological Oncology·Rahul MatnaniGovind Bhagat
May 22, 2008·International Journal of Surgical Pathology·Ying-Chun ZhangWei-Ping Liu
Feb 24, 2018·Histopathology·James A IsomRobert W Allan
Sep 14, 2018·American Journal of Clinical Pathology·Daniel XiaLawrence R Zukerberg
Oct 15, 2019·The American Journal of Surgical Pathology·Rahul KrishnanAlejandro A Gru
Dec 14, 2016·Annual Review of Pathology·Elaine S Jaffe
Aug 15, 2013·Molecular Medicine Reports·Peter MakovickyPeter Kruzliak
Nov 28, 2019·Virchows Archiv : an International Journal of Pathology·Santiago Montes-MorenoMaria Calaminici
Jul 23, 2020·Virchows Archiv : an International Journal of Pathology·Jean-Louis DargentLaurence de Leval
Aug 7, 2019·Blood·Wenbin XiaoElaine S Jaffe
Jan 1, 2021·Histopathology·Periklis G FoukasLaurence de Leval
May 22, 2021·Seminars in Diagnostic Pathology·Swee-Shan Hue SusanSoo-Yong Tan
Dec 28, 2021·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Ye Young KooTae Oh Kim